US Post Office-Lyons is a historic post office building located at Lyons in Wayne County, New York. It was designed and built in 1931–1932 and is one of a number of post offices in New York State designed by the Office of the Supervising Architect of the Treasury Department, James A. Wetmore. It is a 1-story, five-by-six-bay, brick building with a pedimented entrance in the Colonial Revival style.

It was listed on the National Register of Historic Places in 1989.