Universidad Mayor de San Andrés or UMSA (Spanish: Universidad Mayor de San Andrés, lit. 'Higher or Major University of San Andrés') is the leading public university in Bolivia, established since 1830 in the city of La Paz. UMSA is the second-oldest university in Bolivia, after the University of San Francisco Xavier de Chuquisaca (1624).

The university was founded by Andrés de Santa Cruz by Supreme Decree on 25 October 1830. Owing to its being situated in the nation's seat of government, La Paz, the Higher University of San Andrés has since its founding influenced the social life and history of Bolivia. The university's history consists of three well-defined periods. From its inception in 1830 until a June 1930 revolution the university was official. From 1930 to the 1936 advent of the University Rectorate, position filled by Héctor Ormachea Zalles, the university was a semi-autonomous or municipal university. From then until the present, the university has been autonomous.

The building that now hosts the university's main offices, known as Monoblock, is located on Avenue Villazón. It was designed in 1942 by architect Emilio Villanueva and is considered an iconic example of Bolivian architecture. The building is part of a university complex inspired by Pre-Columbian architecture that never fully materialized. Construction started in 1942 and concluded on 4 July 1947. It was criticized for being the first skyscraper in the city.

It is also an epicenter of social movements and many congregate there after marching downtown.

It has 13 floors, 11 of which are used for classrooms. It contains the most complete library in the country, an auditorium that is open to the public for various events, and a semi-subterranean garden with access to the central atrium. The library was created in 1930.

Due to the high demand for rooms, various pavilions and two buildings were built in the surrounding areas. They are separated from Monoblock by open areas and the remnants of the military college, also designed by Villanueva.

The university has the following colleges

• Law and Political Sciences
• Medicine website
• Architecture, Arts, Design, and Planning website Archived 2019-06-09 at the Wayback Machine
• Social Sciences website
• Economics and Finance
• Humanities and Education website
• Pharmaceutical and Biochemical Sciences website
• Engineering website Archived 2020-02-25 at the Wayback Machine
• Mechanics
• Pure and Natural Sciences website (which maintains the Max Schreier Planetarium and the Astronomical Observatory of Patacamaya)
• Dentistry
• Agronomy
• Earth Sciences

• Walter Gonzalez Gonzalez, civil engineer, dean of the UMSA school of engineering, head of Alto Beni project
• Ana Teresa Morales, economist, professor, and politician
• Eduardo del Castillo, lawyer and politician

• Gregorio Baro, Argentine scientist
• Jaime Escalante, Educator
• Eduardo Bayro, Bolivian scientist, expert in geometric algebra
• Takaaki Kajita, Nobel Prize in Physics 2015

• Official page of the Higher University of San Andrés
• List of colleges and majors
• Central Library

16°30′17″S 68°07′48″W / 16.50472°S 68.13000°W / -16.50472; -68.13000