University City High School (UCHS) is a comprehensive four-year public high school in the University City section of San Diego, California, United States. It is part of San Diego Unified School District. The school opened its doors in September 1981. The school was ranked 222nd in 2008 and 297th in 2009 on Newsweek's list of Best U.S. Public High Schools. In 2013, The Washington Post ranked the school as the 602nd most challenging high school in America.

UCHS offers a wide range of instructional programs. The Advanced Placement Program, Gifted and Talented Education (GATE) Program, the seminar program, and the special education program address the needs of identified students. UCHS students have the opportunity to take visual and performing arts courses and practical arts courses.

The school offers 15 AP classes: Biology, Chemistry, Environmental Science, Physics C, Statistics, US Government, US History, World History, English Language and Composition, English Literature and Composition, Art History, Studio Art, Psychology, Computer science and Spanish Language. The school also participates in the Accelerated College Program with San Diego Mesa College to offer Calculus, Linear Algebra, Discrete Mathematics, and Political Science. These classes are taught by Mesa College professors on the University City High School campus. The school also provides some performance programs, such as breakdancing and freestyle dance.

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• UCHS Badminton - CIF Champions: 2005, 2015, 2017
• UCHS Boys' Varsity Soccer - CIF Champions: 2004, 2005, 2011, 2013, 2017
• UCHS Boys' Varsity Soccer - 2011: State semi-finalists
• UCHS Boys' Varsity Basketball - 2011: Centurions 1st Division III CIF
• UCHS Girls' Varsity Softball - 2011, 2010, 2009 CIF Champions
• UCHS Boys' Varsity Track and Field - 2011 CIF Champions
• UCHS Girls’ Varsity Track and Field - 2019 CIF Champions
• UCHS Baseball - 2007 CIF Champions
• UCHS Football - 2022 CIF Champions
• UCHS Girls’ Varsity Field Hockey - 2022 CIF Champions

University City High School offers sports programs for student-athletes.

• UC marching band

SCSBOA state finalists since 2015, with a silver medal in both 2017 and 2018 in the 2A division. Received the gold medal at 2A division championships in 2019, following an undefeated season.

The color palette of the school, as well as their three primary logos, the UC Script, the Centurion, and the UC block logo, are given below. The block logo is used as the "Varsity Letter" style for all varsity letter-earning athletes.

• Yari Allnutt — 2 Time Olympic soccer player
• Tim Patrick – NFL wide receiver for the Detroit Lions
• Matt Brock – professional football player in the National Football League
• Tyler Saladino – Major League Baseball infielder
• Kyle Holder – Major League Baseball shortstop
• Ken Waldichuk - Major League Baseball pitcher
• Mike Saipe – Major League Baseball pitcher
• Rhett Bernstein – soccer player
• Mac Fleet – professional track & field Athlete, 2x NCAA Track and Field National Champion in the 1500m for the University of Oregon
• Jennifer Gross – college basketball coach
• Kent Ninomiya – TV news anchor, reporter and executive
• Félix Sánchez – two-time Olympic gold medalist in the 400 meter hurdles, representing the Dominican Republic

• School website