State Route 72 (SR-72) is a 35.393-mile-long (56.960 km) state highway in the U.S. state of Utah. The current alignment is an extension of SR-10. The highway provides access to Loa from Interstate 70 (I-70).

The highway begins in Loa and proceeds north towards Fremont and across Fishlake National Forest. The portion across Fishlake National Forest is frequently closed during winter weather. While in the national forest the highway passes by landmarks such as Foy Bench and The Frying Pan. The highway ends where SR-10 begins. This is near the Ivie Creek Rest Area along I-70. This junction is called Fremont Junction by most maps and the Utah legislature. Aside from the rest area, no permanent structures exist at this location.

State Route 121 was created in 1931, connecting SR-24 at Loa with Fremont. Two years later, the route was renumbered 72 and extended to Fremont Junction on SR-10. State Route 250 was created in 1953 as a connection from SR-24 between Loa and Lyman north to the 90° turn in SR-72, but was given back to the county in 1969.

With the completion of I-70 along SR-10's alignment, most of the old road was relinquished to Sevier County in 1976. Since there was no interchange at Fremont Junction, SR-72 was extended east about two miles (3 km) to the point where I-70 left the SR-10 alignment to cross the San Rafael Swell. (A short piece of old SR-10 west of SR-72 was restored to the state highway system in 1978 as SR-76.)

County	Location	mi	km	Destinations	Notes
Wayne	Loa	0.000	0.000	SR-24 – Richfield, Torrey	Southern terminus
	Fishlake National Forest	9.629	15.496	Fish Lake
Sevier		17.400	28.003	View area – Hogan's Pass / Willow Basin
		18.513	29.794	View Area – Hogan's Pass Trailhead
	​	33.541	53.979	SR-76 west – Salina	Eastern terminus of SR-76
	​	35.393	56.960	I-70 / US 50 / SR-10 north – Green River, Castle Dale, Price	Northern terminus; southern terminus of SR-10; diamond interchange
1.000 mi = 1.609 km; 1.000 km = 0.621 mi