Uxbridge Secondary School (U.S.S.) is a high school in the Township of Uxbridge, Ontario, and is one of 21 high schools within the Durham District School Board. The school has students from grades 9–12 and offers a wide range of academic and extracurricular activities.

Originally called Uxbridge High School opened in 1872 opposite the then Methodist and now Trinity United Church on First Avenue. The school replaced the Grammar School that opened in 1856. The second school building was erected from 1923 to 1925 and has undergone five major additions since then in 1965, 1979, 1985, 2003, and 2013. The building as it stands today has 81 classrooms, two gymnasiums, a cafeteria, a learning commons/library, and numerous staff and maintenance areas. At one point, there were 13 portables on site, including a "portapack", but these have largely been replaced with a new extension to the school.

The Uxbridge Tigers have earned many awards on Cross-country running and rugby. In 2011, the senior boys won gold at the "AAAA" OFSAA rugby final. During the 2013 OFSAA cross country Finals, the senior girls placed first, achieving a gold medal. 2015-2016 Senior Boys Rugby 15's "AAA" OFSAA champions. 2015-2016 Senior Girls Volleyball "AAA" OFSAA champions. 2015-2016 Senior Boys Volleyball "AAA" OFSAA consolation champions.

• Education in Ontario
• List of secondary schools in Ontario

• Uxbridge Secondary School