Vĩnh Cửu is a rural district of Đồng Nai province in the Southeast region of Vietnam. As of 2003 the district had a population of 106,067. The district covers an area of 1122 km². The district capital lies at Vĩnh An.

The Vĩnh Cửu nature reserve is an area of (mostly secondary) seasonal tropical forest and links directly with Cát Tiên National Park; together they provide contiguous habitat for a number of endangered species including yellow-cheeked gibbons, gaur and Asian elephants. The Trị An lake (hồ) and dam form a substantial part of this district.

Administrative subdivisions

The district is subdivide to a township and 11 rural communes, including:

• Vĩnh An township
• Bình Hòa commune
• Bình Lợi commune
• Hiếu Liêm commune
• Mã Đà commune
• Phú Lý commune
• Tân An commune
• Tân Bình commune
• Thạnh Phú commune
• Thiện Tân commune
• Trị An commune
• Vĩnh Tân commune