The Van Antwerp Building is a high-rise in the U.S. city of Mobile, Alabama. Completed in 1907, the building rises 11 stories and was the first skyscraper in the city. It is regarded as the first reinforced concrete skyscraper in Alabama and the Southeastern United States. In the early 21st century, the 120-foot (37 m) structure is the 8th-tallest building in Mobile.

The building, an example of Beaux-Arts architecture, was designed by architect George Bigelow Rogers for Garet Van Antwerp, a wealthy Mobile druggist. The tower was built to house his pharmacy store, with other offices on the upper floors. It remained in operation on the building's ground floor until the 1960s.

The Van Antwerp Building was purchased by the Retirement Systems of Alabama in 2013. It was unoccupied except for a first-floor restaurant, and the building was deteriorating and in bad repair. It was completely restored and enlarged from 2014 through 2016, including historical restoration of the terracotta exterior, reinstalling the decorative cornice (removed in the 1950s), new windows, structural repairs, first floor historical renovation, and new MEP systems. The building was brought up to all current building and life safety codes. The Van Antwerp Building is now a fully operational, completely occupied office building in the heart of downtown Mobile.

• List of tallest buildings in Mobile

Preceded by Cathedral Basilica of the Immaculate Conception

Tallest Building in Mobile 1907—1929 37m

Succeeded by Regions Bank Building