The Varzob (Tajik: Варзоб, Russian: Варзоб, in the lower reaches also Dushanbinka) is a right tributary of the river Kofarnihon in Tajikistan. It is 71 kilometres (44 mi) long and has a basin area of 1,740 square kilometres (670 sq mi).

The Varzob rises on the southern flank of the Gissar Mountains, and flows south. It passes through the Varzob District, the town Varzob and through the Tajik capital Dushanbe.