State Route 352 (SR 352) is a primary state highway in the U.S. state of Virginia. Known as St. Charles Road, the state highway runs 2.40 miles (3.86 km) from U.S. Route 421 (US 421) near Pennington Gap to SR 634 and SR 636 in St. Charles in northern Lee County.

Route description

SR 352 begins at an intersection with US 421 on the north side of Stone Mountain and west of Pennington Gap. The state highway follows Straight Creek and Norfolk Southern's St. Charles Branch rail line north to the town of St. Charles. Within the town, the state highway reaches its northern terminus at a three-way intersection with SR 634 (Bonny Blue Road) and SR 636 (Monarch Road).

Major intersections

The entire route is in Lee County.

Location	mi	km	Destinations	Notes
Stone Creek	0.00	0.00	US 421 – Pennington Gap, Harlan	Southern terminus
St. Charles	2.40	3.86	SR 634 (Bonny Blue Road) / SR 636 (Monarch Road) – Bonny Blue	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi