Lake Vygozero (Russian: Выгозеро, romanized: Vygozero; Finnish: Uikujärvi) is a large freshwater lake in the Republic of Karelia, in the northwestern part of Russia. It has an area of 1,250 km (480 sq mi), and is part of the Vyg drainage in the White Sea basin.

From 1933 it has been a part of the White Sea–Baltic Canal. There are more than 500 islands on the lake. Vygozero is used for its fishing. The Upper Vyg and Segezha empty into the lake.