State Trunk Highway 125 (often called Highway 125, STH-125 or WIS 125) is a 2.62-mile (4.22 km) state highway in Outagamie County in the US state of Wisconsin. It runs from Interstate 41 (I-41) in the Town of Grand Chute east to WIS 47 in Appleton; the route is located entirely within these two municipalities. WIS 125 is maintained by the Wisconsin Department of Transportation (WisDOT).

WIS 125 begins at a junction with I-41 and County Trunk Highway CA (CTF-CA) in the Town of Grand Chute. From here, the route heads east as a divided highway called College Avenue, passing through a business district. It meets CTF-AA (Bluemound Drive) before passing a baseball diamond. After entering Appleton, the highway meets CTF-A (Lynndale Drive). Past this junction, the route crosses the Canadian National Railway. The highway runs through a mixed residential and business area, passing to the south of Wilson Middle School. After crossing Badger Avenue, WIS 125 terminates at a junction with WIS 47; College Avenue continues east of the intersection. Valley Transit's Route 15 West College bus serves much of WIS 125, including the entire eastern half of the road.

The entire route is in Outagamie County.

Location	mi	km	Destinations	Notes
Town of Grand Chute	0.0	0.0	I-41 / US 41 – Green Bay, Milwaukee CTH-CA west	Western terminus
	0.27	0.43	CTH-AA
Appleton	1	1.6	CTH-A
	2.5	4.0	WIS 47 (Richmond Street, Memorial Drive)	Eastern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• U.S. Roads portal

• Media related to Wisconsin Highway 125 at Wikimedia Commons