State Trunk Highway 52 (often called Highway 52, STH-52 or WIS 52) is a state highway in the U.S. state of Wisconsin. It runs east–west in central and northeastern Wisconsin from Wabeno to Wausau. It is one of four state highways that also serve Antigo.

Running from west to east, WIS 52 begins at an interchange with the WSI 29 freeway segment near Rib Mountain. Almost immediately, WIS 52 also has an interchange with the U.S. Highway 51 (US 51) freeway, which serves as Wausau's western bypass. It then enters Wausau as Stewart Street, crossing the Wisconsin River into downtown.

In downtown Wausau, WIS 52 runs on one-way streets in a loop around the central business district; the eastbound lanes join Business US 51 northbound, run around the Wausau Center shopping mall, and then back north via 6th Street. Meanwhile, the westbound lanes run along southbound Business US 51 past Athletic Park, home of the Northwoods League Wausau Woodchucks baseball team, and also past the Dudley Tower, the tallest commercial building in Wisconsin outside of the Milwaukee area.

Northeast of Wausau, WIS 52 runs past Hogerty, with access to the Dells of the Eau Claire River Park, a popular recreational park and campground known for its rock formations and waterfalls; the Ice Age Trail also runs through the park.

Just past Marathon County, WIS 52 meets up with US 45 and joins it for the drive north to Antigo, the Langlade County seat. WIS 47 and WIS 64 also intersect WIS 52 along this stretch. From Antigo, WIS 52 zigzags northeast past Lily, where it has a junction with WIS 55 along the Wolf River. The road then enters the Nicolet National Forest and into Forest County before ending at WIS 32 just northwest of Wabeno.

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  The northern terminus with WIS 32 near Wabeno
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  A kayak statue along the Wisconsin River as WIS 52 enters downtown Wausau near the Dudley Tower

County	Location	mi	km	Destinations	Notes
Marathon	Wausau	0.0	0.0	WIS 29 west – Abbotsford, Chippewa Falls	Western terminus of WIS 52
		0.9	1.4	US 51 to WIS 29 east – Merrill, Stevens Point, Green Bay
		2.3	3.7	Bus. US 51	Brief concurrency to cross the Wisconsin River
Shawano	Aniwa	27.6	44.4	US 45 south – Birnamwood, Wittenberg, Clintonville	Southern end of US 45 concurrency
Langlade	Town of Rolling	31.2	50.2	WIS 47 south – Keshena	Southern end of WIS 47 concurrency
	Antigo	38.4	61.8	US 45 north / WIS 47 north – Monico WIS 64 west – Merrill	Northern end of US 45/WIS 47 concurrency; western end of WIS 64 concurrency
	Langlade	39.8	64.1	WIS 64 east – Langlade	Eastern end of WIS 64 concurrency
	Lily	58.5	94.1	WIS 55 north – Crandon	Northern end of WIS 55 concurrency
		58.7	94.5	WIS 55 south – Langlade	Southern end of WIS 55 concurrency
Forest	Wabeno	74.91	120.56	WIS 32 – Laona, Wabeno	Eastern terminus of WIS 52
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• U.S. Roads portal

• Media related to Wisconsin Highway 52 at Wikimedia Commons