Wayne County High School is located in Jesup, Georgia, United States. It is the only public high school in Wayne County.

The school was founded in 1966 from the consolidation of Jesup, Odum, Screven and Northside high schools. Originally located on Orange Street, it moved to its current campus in 2002. However in 2022 only Baseball Football and Softball are held at the original campus.

Wayne County's mascot is the Yellow Jacket. Sports offered include:

• Baseball
• Basketball
• Cross country
• Football
• Golf
• Marching band
• Soccer
• Softball
• Swimming
• Tennis
• Track
• Wrestling

Clubs offered include:

• Beta
• Café
• Drama
• FBLA
• FCA
• FFA
• HOSA
• STEM (Science, Technology, Engineering, and Math club)
• Student Council
• Y-Club
• Yearbook
• JROTC

The school's fight song is sung to the tune of the "Washington and Lee Swing".

• Baseball (1) - 1967(2A)
• Football (1) - 1959(2A)
• Slow Pitch Softball (1) - 1998(3A/4A)

• Football (1) - 1954(A)
• Literary (6) - 1947(B), 1948(B), 1949(B), 1951(B), 1952(B), 1954(A)

"We honor thee for all you've done to help us great and small. We stand erect with heads unbowed to ever heed thy call. Honor the gold and the white; hold them high! Cling to the things that are right, Wayne County High! Cherish the memories of days that were bright, and forget every cloud in the sky, Hail to Wayne County High!"

• Barret Browning - former professional baseball player
• Len Hauss - former NFL football player
• Tre' Jackson - former NFL football player
• Greyson Lambert - former college football and baseball player
• T. Y. McGill - current NFL football player
• Lindsay Scott - former NFL football player
• Trevin Wallace - college football player
• John Warren - former NFL football player

• Wayne County High School
• Wayne County Schools