Wells Creek is an unincorporated community in Anderson County, located in the U.S. state of Texas. It is located within the Palestine, Texas micropolitan area.

Wells Creek is named for the nearby Wells Creek, which was also named for Samuel G. Wells, who was issued a grant for the land that the community and a majority of the creek are located today. It had a flag stop station and several scattered houses in the 1930s, and only one home was located in the community in 1982.

Wells Creek sits on Farm to Market Road 3266, along the Missouri Pacific Railroad and near Wells Creek, 4 mi (6.4 km) east of Palestine in the eastern portion of Anderson County.

Public education in Wells Creek is provided by the Palestine Independent School District.