The Wells Fargo Building is a historic office building in downtown Portland, Oregon, United States. The large doorstep at the building's entryway required the largest slab of granite ever shipped to Portland at the time. Completed in 1907, the steel-framed building is considered the city's first true skyscraper. At 12 stories and with a height of 182 feet (55 m), it was the tallest building in Portland (and indeed in all of Oregon), exclusive of towers, and remained so for four years. The clock tower of the 1892-completed Oregonian Building, which measured 194 feet (59 m) in height, made that building the tallest in the city overall.

In 1946, the building was purchased by the United States National Bank of Portland, whose headquarters was located in a smaller building located directly adjacent, immediately to the south. U.S. National Bank used the Wells Fargo Building to expand its downtown Portland headquarters.

In 1986, the building was placed on the National Register of Historic Places.

• Architecture of Portland, Oregon
• National Register of Historic Places listings in Southwest Portland, Oregon

• Media related to Wells Fargo Building (Portland, Oregon) at Wikimedia Commons
• Portland Business Journal: Portland's first skyscraper passes the century mark