The West Chester Downtown Historic District is a national historic district that is located in West Chester, Chester County, Pennsylvania, United States.

It was listed on the National Register of Historic Places in 1985.

This district encompasses 3,137 contributing buildings in West Chester. It includes residential, commercial, institutional, and industrial buildings that were built between 1789 and the 1930s. Notable buildings include the U.S. Post Office (1907), the Green Tree Building (1933), St. Agnes Church (1851), the Biddle Street School (1917), the Major Groff Memorial Armory, the Horticulture Building (1848) that was designed by Thomas U. Walter, the Denney-Reyburn factory, the Caleb Taylor Store (c. 1818), Federal Ehne's Bakery (c. 1816), Kofke's Store (c. 1816), and the Woolworth building (1928). Also listed and located in the district are the Bank of Chester County, the Buckwalter Building, the Chester County Courthouse, the Farmers and Mechanics Building, and the Warner Theater.

This district was listed on the National Register of Historic Places in 1985. The boundary was increased on February 27, 2005.

• Media related to West Chester Downtown Historic District at Wikimedia Commons
• Chester County Horticultural Hall, 225 North High Street, West Chester, Chester County, PA: 8 photos and 13 data pages at Historic American Buildings Survey
• Chester County Hotel, 36 West Market Street, West Chester, Chester County, PA: 4 photos, 5 data pages, and 1 photo caption page at Historic American Buildings Survey
• Chester County Prison, 235 West Market Street, West Chester, Chester County, PA: 19 photos and 19 data pages at Historic American Buildings Survey
• Baptist Church of West Chester, 221 South High Street, West Chester, Chester County, PA: 2 photos, 11 data pages, and 1 photo caption page at Historic American Buildings Survey