Wierzbno [ˈvjɛʐbnɔ] is a village in the administrative district of Gmina Słupca, within Słupca County, Greater Poland Voivodeship, in west-central Poland. It lies approximately 4 kilometres (2 mi) south of Słupca and 68 km (42 mi) east of the regional capital Poznań.

As part of the region of Greater Poland, i.e. the cradle of the Polish state, the area formed part of Poland since its establishment in the 10th century. Wierzbno was a private church village of the monastery in Ląd, administratively located in the Konin County in the Kalisz Voivodeship in the Greater Poland Province of the Kingdom of Poland.

During the German occupation of Poland (World War II), in 1940, the German gendarmerie carried out expulsions of Poles, who were then placed in a transit camp in Łódź, while their houses and farms were handed over to German colonists as part of the Lebensraum policy. Expelled Poles were eventually either enslaved as forced labour of new German colonists in the county or deported to the General Government in the more eastern part of German-occupied Poland.