William L. Sayre High School (commonly referred to as Sayre High School) is a high school in Philadelphia and a part of the School District of Philadelphia. It was founded in 1949 as a middle school serving grades 7–9, becoming a high school in 2003. Sayre High School is also the home site of SHIELD (Sayre Health Initiatives Education and Leadership Development), a Sayre Health Center run enrichment program providing medical assistant training, health professions education, internship employment and scholarship opportunities for School District of Philadelphia high school students.