William Poeschel House, also known as the Poeschel-Harrison House, is a historic home located near Hermann, Gasconade County, Missouri. It was built about 1869, and is a two-story, ell-shaped, red brick dwelling. It features a two-story, gable-roofed portico, and a two-story porch that spans the east side of the rear ell.

It was listed on the National Register of Historic Places in 1990.