The William Sloane House (also known as the William and Frances Crocker Sloane House) is a mansion located on 686 Park Avenue between 68th and 69th Streets in the Upper East Side of New York City.

It was constructed for the industrialist William Sloane and his wife Frances Crocker Sloane in 1919 by Delano & Aldrich in the Colonial Revival style as one of the Park Avenue Houses.

It changed ownership multiple times. Today the Italian Cultural Institute of New York is located there, next to the adjacent Italian consulate-general.

The House became a New York City designated landmark in 1970 and is listed on the National Register of Historic Places as part of the Park Avenue Houses.