William Waddell House is a historic home located near Grassy Creek, Ashe County, North Carolina. It was built between 1820 and 1830, and is a two-story, three-bay, "L" plan brick dwelling with a one-story ell. The interior was restored after a fire about 1868–1871. Also on the property is a contributing log granary (c. 1875) and family cemetery.

It was listed on the National Register of Historic Places in 1976.