The Woodberry-Quarrels House is a historic First Period house in Hamilton, Massachusetts. The oldest part of this 2.5-story, seven-bay wood-frame house is the central doorway and the rooms to its right, which were built c. 1690 along with a central chimney that was probably removed during Federal-period alterations. Later in the First Period rooms to the left of the entry were added, and there have been a series of alterations and additions since then. The First Period core of the house survived the major Federal-era changes, and the house retains much decorative work from that period.

The house was listed on the National Register of Historic Places in 1990.

• List of the oldest buildings in the United States
• National Register of Historic Places listings in Essex County, Massachusetts