Wyoming Highway 22 (WYO 22) is a 17.53-mile-long (28.21 km) state highway in the U.S. State of Wyoming known as the Teton Pass Highway in Teton County Wyoming. WYO 22 spans 17.53 miles (28.21 km) from Idaho State Highway 33 at the Idaho-Wyoming state line to the concurrency of U.S. Routes 26, 89, 189, and 191 in Jackson.

At the state line, Idaho State Highway 33 continues as WYO 22 and climbs to Teton Pass at 8,431 feet (2,570 m) above sea level. It then descends and passes through the community of Wilson, a census-designated place (CDP) west of Jackson. On the eastern border of Wilson, at 13.51 miles (21.74 km), WYO 22 intersects the southern terminus of Wyoming Highway 390 (Moose-Wilson Road) before crossing the Snake River. WYO 22 then continues east to Jackson where it ends at U.S. Highway 26/89/189/191 (Broadway).

WYO 22 used to connect to former Alternate US 20, which began at U.S. Highway 20 in Sugar City, Idaho, following Idaho 33 until the state line, then connected with WYO 22. Alternate US 20 used to end at the state line, where it was redesignated as WYO 22, as Wyoming did not extend the route into the state. If that route had been extended, it would have taken over the entire route of WYO 22, to then overlap U.S. Highway 26 until it reached U.S. Highway 20 in Shoshoni.

On June 8, 2024, WYO 22 suffered a “catastrophic” failure when a portion of the road collapsed in a landslide at milepost 12.8 (43°30′13″N 110°58′32″W / 43.5035°N 110.9756°W / 43.5035; -110.9756 (Landslide Site)), less than five miles (8 km) by air from the Idaho border. A 600-ft detour, constructed by a contractor of the Wyoming Department of Transportation, was opened to traffic on June 28, 2024. The detour has a sharper curvature and a grade of 11.2 percent (the original road built in the 1960s had a 10 percent grade), with a reduced speed limit of 20 mph, but the former 60,000 lbs gross vehicle weight restriction remains.

The entire route is in Teton County.

Location	mi	km	Destinations	Notes
​	0.00	0.00	SH-33 west	Western terminus, 6,690 ft (2,040 m)
​	6.40	10.30	Teton Pass, 8,431 ft (2,570 m)
Wilson–Moose Wilson Road line	13.51	21.74	WYO 390 north (Moose-Wilson Road) – Teton Village	Southern terminus of WYO 390
	13.80	22.21	Bridge over the Snake River
Jackson	17.53	28.21	US 26 / US 89 / US 189 / US 191 (Broadway) – Hoback Junction, Jackson	Eastern terminus, 6,155 ft (1,876 m)
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• List of highways numbered 22
• List of state highways in Wyoming

• Wyoming Routes 00-99
• WYO 22 - US 26/US 89/US 189/US 191 to WYO 390
• WYO 22- WYO 390 to ID 33/Idaho State Line