Wyoming Highway 351 (WYO 351) is a 24.18-mile-long (38.91 km) east-west Wyoming state road located in central Sublette County. It connects U.S. Route 189 (US 189) with US 191 and mainly serves the hugely important Big Piney-Rock Springs corridor.

Route description

Wyoming Highway 351 begins its western end east of the Big Piney-Marbleton Airport at U.S. Route 189, 2 miles north of Marbleton and 3 miles north of Big Piney. Highway 351 travels east and crosses the Green River at 7.30 miles (11.7 km) and shortly after intersects Sublette CR 110 and 175. Now WYO 351 runs along the north side of the New Fork River, a tributary of the Green River, and parallels it for a few miles before crossing it at approximately 12.90 miles (20.8 km). WYO 351 reaches its eastern terminus at US 191 at just over 24 miles, 11 miles south of Boulder.

Major intersections

The entire route is in Sublette County.

Location	mi	km	Destinations	Notes
​	0.00	0.00	US 189
​	24.18	38.91	US 191
1.000 mi = 1.609 km; 1.000 km = 0.621 mi