Wyoming Highway 78 (WYO 78) is a 1.23-mile (1.98 km) long Wyoming state highway located in Carbon County in the city of Rawlins. The highway runs along a portion of South Higley Boulevard.

Wyoming Highway 78, albeit short in length, serves as a connection between Highway 71, Interstate 80, and U.S. Route 30 at exit 214, and the Wyoming State Penitentiary to the south. Highway 78 begins at the Wyoming State Penitentiary south of Rawlins, and heads north along South Higley Boulevard. Highway 78 intersects I-80 / US 30 at exit 214, and just 0.15 miles (0.24 km) later terminates at Highway 71.

Mileposts increase from north to south along Highway 78.

The entire route is in Rawlins, Carbon County.

mi	km	Destinations	Notes
0.00	0.00	Wyoming State Penitentiary	Southern terminus
1.08	1.74	I-80 / US 30 – Rock Springs, Laramie	Exit 214 on I-80 / US 30
1.23	1.98	WYO 71 south / South Higley Boulevard north	Northern terminus; northern terminus of WYO 71
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• U.S. Route 287, which carries the name North Higley Boulevard in Rawlins

• Official 2003 State Highway Map of Wyoming

• Wyoming State Routes 000-099
• WYO 78 - Wyoming State Penitentiary to I-80/US 30
• WYO 78 - I-80/US 30 to WYO 71
• City of Rawlins website
• Wyoming State Penitentiary