Yookamurra Sanctuary is a 50 km private protected area in the Murraylands region of South Australia, between the eastern slopes of the Mount Lofty Ranges and the Murray River, 24 km north-east of the town of Sedan. It is owned and managed by the Australian Wildlife Conservancy (AWC).

Yookamurra is a consolidation of several properties acquired by Earth Sanctuaries for wildlife conservation from the late 1980s to 1998, before being purchased by AWC in 2002.

The reserve consists of gently undulating country with shallow soils overlying calcrete, at an altitude of 80-90 m. It lies at the southern end of the semi-arid zone of South Australia and the climate is one of cool winters and hot summers. The average annual rainfall, mainly falling in winter, is 270 mm.

Most of Yookamurra's habitats are variations of mallee woodlands and shrublands.

Threatened fauna species include malleefowl, emu, southern hairy-nosed wombat, western grey kangaroo, red kangaroo, numbat, greater bilby, boodie, woylie and short-beaked echidna. An attempted reintroduction of the greater stick-nest rat failed.

• Official webpage
• Webpage on the Protected Planet website