Zacisze [zaˈt͡ɕiʂɛ] is a settlement in the administrative district of Gmina Supraśl, within Białystok County, Podlaskie Voivodeship, in north-eastern Poland. It lies approximately 5 kilometres (3 mi) north-east of Supraśl and 20 km (12 mi) north-east of the regional capital of Białystok.