The Zarzis Synagogue (Arabic: كنيس جرجيس; Hebrew: בית הכנסת משכן יעקב, romanized: Beit HaKnesset Mishkan Ya’akov, lit. 'Mishkan Yaakov Synagogue'), is a Jewish congregation and synagogue, located in the coastal town of Zarzis, Tunisia. The synagogue was completed in 1905, when the Jewish community of Zarzis numbered approximately 1,000.

An arson attack in 1982, following Sabra and Shatila massacre in Lebanon, left the synagogue and Torah scrolls totally destroyed. It was subsequently rebuilt and used by the town's remaining 150 Jews.

The lavishly decorated synagogue leads into an open-air courtyard which has adjoining rooms which serve as the talmud torah. As of 2007, Rabbi Eliyahu Sofer was the head of the community.

• History of the Jews in Tunisia
• List of synagogues in Tunisia