Zastrużne [zasˈtruʐnɛ] (German: Sastrosnen) is a village in the administrative district of Gmina Orzysz, within Pisz County, Warmian-Masurian Voivodeship, in northern Poland. It lies approximately 12 kilometres (7 mi) north-west of Orzysz, 27 km (17 mi) north of Pisz, and 86 km (53 mi) east of the regional capital Olsztyn.

The village has a population of 80.