Zehe Building, also known as the Ozark Hotel, was a historic commercial building located at Poplar Bluff, Butler County, Missouri. It was built in 1911, and is a three-story, rectangular brick building with Colonial Revival style design influences. It had a hipped roof and sits on a stone and concrete foundation. The central bay of the front facade features concrete balconies on both upper floors. The building contained a hotel and other businesses until the 1980s. As of 1/2018 it no longer exists.

It was added to the National Register of Historic Places in 1994.