Berlin Südkreuz station (German: Bahnhof Berlin Südkreuz, lit. 'Berlin South Cross') is a railway station in the German capital Berlin. The station was originally opened in 1898 and is an interchange station. The Berlin Ringbahn line of the Berlin S-Bahn metro railway is situated on the upper level and connects to the east and west, whilst the Anhalter Bahn and Dresdner Bahn intercity railway routes reach the station on the lower, north-south level. The station was extensively rebuilt between the late 1990s and 2006, and was renamed Berlin Südkreuz on 28 May 2006.

The station's original name (Berlin Papestraße) originates from the nearby General-Pape-Straße, which is named after the Prussian general Alexander August Wilhelm von Pape. The Ringbahn platform opened as an island platform on 1 December 1901.

The original Papestrasse station building, constructed from 1898 to 1901 was demolished, although a corner of the building, incorporating a clock tower, has been preserved as part of the new station.

The station played a vital part in Deutsche Bahn's new concept for long-distance services in Berlin; it was deemed necessary to have a long-distance station in southern Berlin for the new north-south axis, so it was decided to rebuild Papestraße and rename the station to Südkreuz, giving the station a more intuitive name like the Ostkreuz (East Cross) and Westkreuz (West Cross) stations on the Berlin Stadtbahn. Construction, however, was severely delayed due to unexpected difficulties and NIMBY complaints of residents living near the long-disused north-south lines. Instead of opening in 2000 as scheduled, the station only opened on 28 May 2006, together with the new Berlin Hauptbahnhof (Berlin Main Station) in the center of Berlin. It is now used as a terminal station for ICE trains to Hamburg Hauptbahnhof, and sees a number of north-south services heading to and from Leipzig Hauptbahnhof or Halle Hauptbahnhof plus EuroCity services to the Czech Republic, Hungary and Slovakia via Dresden Hauptbahnhof.

After upgrades on the Berlin Dresden railway, the airport express (FEX) is to run via Südkreuz.

During 2017 Germany's Ministry of the Interior announced a pilot project to employ facial recognition technology at Berlin Südkreuz station. The six-month trial will overlay facial recognition software over the station's existing video surveillance system and will track a database of volunteers. The project is being jointly undertaken by the Ministry of the Interior, the Federal Police, the Federal Criminal Police Office and Deutsche Bahn. Announcing the pilot, the ministry said the technology would be able to detect people in need of help, as well as suspicious behaviour, and report it automatically.

The station is served by the following service(s):

Line	Route	Interval
ICE 8	Berlin Gesundbrunnen – Berlin – Berlin Südkreuz – Halle – Erfurt – Nuremberg – Munich	Every 2 hours
ICE 9	Berlin Südkreuz – Berlin – Cologne – Bonn
ICE 11	Berlin Gesundbrunnen – Berlin – Berlin Südkreuz – Leipzig – Erfurt – Frankfurt – Mannheim – Stuttgart – Munich – Innsbruck	Every 2 hours
ICE 15	(Rostock –) Berlin Hbf – Berlin Südkreuz – Halle – Erfurt – Frankfurt (– Saarbrücken, Stuttgart or Darmstadt)	Every 2 hours
ICE 18	(Kiel –) Hamburg – Berlin Hbf – Berlin Südkreuz – Halle – Erfurt – Nuremberg – Ingolstadt/Augsburg – Munich	Every 2 hours
ICE 28	Hamburg – or (Binz – Stralsund –) Berlin Hbf – Berlin Südkreuz – Leipzig – Erfurt – Nuremberg – Ingolstadt/Augsburg – Munich	Every 2 hours
ICE 29	(Rostock –) Berlin Hbf – Berlin Südkreuz – Halle – Erfurt – Nuremberg – Munich	5 train pairs
ICE 91	(Rostock –) Berlin Hbf – Berlin Südkreuz – Halle – Erfurt – Nürnberg – Regensburg – Passau – Linz – Vienna	One train pair
IC 17	Warnemünde – Rostock – Waren – Neustrelitz – Oranienburg – Berlin Gesundbrunnen – Berlin Hbf – Berlin Südkreuz – BER Airport – Terminal 1-2 – Doberlug-Kirchhain – Elsterwerda – Dresden-Neustadt – Dresden	Every 2 hours
EC 27	(Kiel or Westerland  –) Hamburg – Berlin Hbf – Berlin Südkreuz – Dresden – Prague (– Budapest)	Every 2 hours
FLX 30	Leipzig – Berlin Südkreuz – Berlin Hbf – Berlin-Spandau – Hannover – Bielefeld – Dortmund – Essen – Duisburg – Düsseldorf – Cologne – Aachen	1 train pair
Notes.	1 = one pair of trains each 2 = one train on line 11 to Kiel, one train on line 18 from Kiel 3 = train stops either in Ingolstadt, in Augsburg and Munich-Pasing or runs between Nuremberg and Munich without intermediate stops 4 = one train only towards Graz

Line	Route
RE 3	Lutherstadt Wittenberg – Jüterbog – Berlin Südkreuz – Eberswalde – Angermünde –		Schwedt (Oder)
			Prenzlau – Greifswald – Stralsund
RE 4	Falkenberg (Elster) – Jüterbog – Ludwigsfelde – Berlin Südkreuz – Berlin-Spandau – Dallgow-Döberitz – Wustermark – Rathenow
RE 5	Berlin Südkreuz – Berlin Potsdamer Platz – Berlin Gesundbrunnen – Oranienburg – Neustrelitz –		Güstrow – Rostock
			Neubrandenburg – Stralsund
RE 8	Berlin Hauptbahnhof – Berlin Potsdamer Platz – Berlin Südkreuz – Wünsdorf-Waldstadt – Luckau-Uckro –		Doberlug-Kirchhain – Elsterwerda
			Finsterwalde (Niederlausitz)
RB 10	Berlin Südkreuz – Berlin Potsdamer Platz – Berlin Hauptbahnhof – Berlin Jungfernheide – Berlin-Spandau – Falkensee – Nauen
RB 14	Berlin Südkreuz – Berlin Potsdamer Platz – Berlin Hauptbahnhof – Berlin Jungfernheide – Berlin-Spandau – Falkensee – Nauen
As of 11 December 2022

• Berlin S-Bahn services Bernau - Karow - Pankow - Gesundbrunnen - Friedrichstraße - Potsdamer Platz - Südkreuz - Blankenfelde
• Berlin S-Bahn services Hennigsdorf - Tegel - Gesundbrunnen - Friedrichstraße - Potsdamer Platz - Südkreuz - Lichterfelde - Teltow
• Berlin S-Bahn services Blankenburg - Pankow - Gesundbrunnen - Friedrichstraße - Potsdamer Platz - Südkreuz - Lichterfelde - Teltow
• Berlin S-Bahn services (Ring Clockwise) Südkreuz - Innsbrucker Platz - Westkreuz - Westend - Jungfernheide - Gesundbrunnen - Ostkreuz - Treptower Park - Hermannstraße - Südkreuz
• Berlin S-Bahn services (Ring Anti-clockwise) Südkreuz - Hermannstraße - Treptower Park - Ostkreuz - Gesundbrunnen - Jungfernheide - Westend - Westkreuz - Innsbrucker Platz - Südkreuz
• Berlin S-Bahn services Südkreuz - Neukölln - Schöneweide - Berlin-Brandenburg Airport (T1-T2)
• Berlin S-Bahn services Westend - Westkreuz - Innsbrucker Platz - Südkreuz - Neukölln - Schöneweide - Grünau - Königs Wusterhausen