In the 2016 election, Darrell Issa won by a margin of less than 1%. In the 2018 election, this district was considered to be a major battleground. Rep. Issa announced that he would not seek reelection. Following the November 6, 2018, election, DemocratMike Levin became the district's congressman.
As of the 2020 redistricting, California's 49th congressional district is located in Southern California. It covers the North County region of San Diego County, and south east Orange County.
San Diego County is split between this district, the 48th district and the 50th district. They are partitioned by Gavilan Mountain Rd, Sandia Creek Dr, De Luz Rd, Marine Corps Base Pendleton, Sleeping Indian Rd, Tumbleweed Ln, Del Valle Dr, Highland Oak St, Olive Hill Rd, Via Puerta del Sol, N River Rd, Highway 76, Old River Rd, Little Gopher Canyon Rd, Camino Cantera, Corre Camino, Tierra del Cielo, Elevado Rd, Vista Grande Dr, Warmlands Ave, Queens Way, Canciones del Cielo, Camino Loma Verde, Alessandro Trail, Friendly Dr, Edgehill Rd, Catalina Heights Way, Deeb Ct, Foothill Dr, Clarence Dr, Highway S14, Smilax Rd, Poinsetta Ave, W San Marcos Blvd, Diamond Trail Preserve, S Rancho Santa Rd, San Elijo Rd, Rancho Summitt Dr, Escondido Creek, El Camino del Norte, San Elijo Lagoon, Highland Dr, Avacado Pl, Jimmy Durante Blvd, San Dieguito Dr, 8th St, Nob Ave, Highway S21, and the San Diego Northern Railway. The 49th district takes in the cities of Carlsbad, Oceanside, Encinitas, Solana Beach, Del Mar, and Vista as well as the census-designated places Camp Pendleton Mainside and Camp Pendleton South.
Orange County is split between this district, the 40th district, and the 47th district. They are partitioned by Alicia Parkway, Pacific Park Dr, San Joaquin Hills Trans Corridor, Cabot Rd, San Diego Freeway, Via Escolar, Arroyo Trabuco Creek, Oso Parkway, Thomas F Riley Wilderness Park, and Ronald W Casper's Wilderness Park, Aliso & Wood Canyons, Vista del Sol, Highway 1, Stonington Rd, Virginia Way, 7th Ave, and Laguna Beach. The 49th district takes in the cities of San Clemente, San Juan Capistrano, Dana Point, and Laguna Niguel, as well as the census-designated places Ladera Ranch, Las Flores, and Rancho Mission Viejo.
Before the 2002 redistricting, most of the territory currently located in the district was previously located in the 48th district. The 49th district was located farther south, encompassing most of what is now the 53rd district.
2003-13
Before the 2012 redistricting the district extended further inland to include a portion of southern Riverside County and most of northern San Diego County.