Christopher Columbus (/kəˈlʌmbəs/; between 25 August and 31 October 1451 – 20 May 1506) was an Italian explorer and navigator from the Republic of Genoa who completed four Spanish-based voyages across the Atlantic Ocean sponsored by the Catholic Monarchs, opening the way for the widespread European exploration and colonization of the Americas. His expeditions were the first known European contact with the Caribbean and Central and South America.

The name Christopher Columbus is the anglicization of the Latin Christophorus Columbus. Growing up on the coast of Liguria, he went to sea at a young age and traveled widely, as far north as the British Isles and as far south as what is now Ghana. He married Portuguese noblewoman Filipa Moniz Perestrelo, who bore a son, Diego, and was based in Lisbon for several years. He later took a Castilian mistress, Beatriz Enríquez de Arana, who bore a son, Ferdinand.

Largely self-educated, Columbus was knowledgeable in geography, astronomy, and history. He developed a plan to seek a western sea passage to the East Indies, hoping to profit from the lucrative spice trade. After the Granada War, and Columbus's persistent lobbying in multiple kingdoms, the Catholic Monarchs, Queen Isabella I and King Ferdinand II, agreed to sponsor a journey west. Columbus left Castile in August 1492 with three ships and made landfall in the Americas on 12 October, ending the period of human habitation in the Americas now referred to as the pre-Columbian era. His landing place was an island in the Bahamas, known by its native inhabitants as Guanahani. He then visited the islands now known as Cuba and Hispaniola, establishing a colony in what is now Haiti. Columbus returned to Castile in early 1493, with captured natives. Word of his voyage soon spread throughout Europe.

Columbus made three further voyages to the Americas, exploring the Lesser Antilles in 1493, Trinidad and the northern coast of South America in 1498, and the east coast of Central America in 1502. Many names he gave to geographical features, particularly islands, are still in use. He gave the name indios ("Indians") to the indigenous peoples he encountered. The extent to which he was aware the Americas were a wholly separate landmass is uncertain; he never clearly renounced his belief he had reached the Far East. As a colonial governor, Columbus was accused by some of his contemporaries of significant brutality and removed from the post. Columbus's strained relationship with the Crown of Castile and its colonial administrators in America led to his arrest and removal from Hispaniola in 1500, and later to protracted litigation over the privileges he and his heirs claimed were owed to them by the crown.

Columbus's expeditions inaugurated a period of exploration, conquest, and colonization that lasted for centuries, thus bringing the Americas into the European sphere of influence. The transfer of plants, animals, precious metals, culture, human populations, technology, diseases, and ideas between the Old World and New World that followed his first voyage are known as the Columbian exchange. These events and the effects which persist to the present are often cited as the beginning of the modern era.

Columbus was widely celebrated in the centuries after his death, but public perception fractured in the 21st century due to greater attention to the harms committed under his governance, particularly the beginning of the depopulation of Hispaniola's indigenous Taíno people, caused by Old World diseases and mistreatment, including slavery. Many places in the Western Hemisphere bear his name, including the South American country of Colombia, the Canadian province of British Columbia, the American city Columbus, Ohio, and the U.S. capital, the District of Columbia.

Columbus's early life is obscure, but scholars believe he was born in the Republic of Genoa between 25 August and 31 October 1451. His father was Domenico Colombo, a wool weaver who worked in Genoa and Savona, and owned a cheese stand at which young Christopher worked. His mother was Susanna Fontanarossa. He had three brothers—Bartholomew, Giovanni Pellegrino, and Giacomo (also called Diego)—as well as a sister, Bianchinetta. Bartholomew ran a cartography workshop in Lisbon for at least part of his adulthood.

His native language is presumed to have been a Genoese dialect (Ligurian) as his first language, though Columbus probably never wrote in it. His name in 15th-century Genoese was Cristoffa Corombo, in Italian, Cristoforo Colombo, and in Spanish Cristóbal Colón.

In one of his writings, he says he went to sea at 14. In 1470, the family moved to Savona, where Domenico took over a tavern. Some modern authors have argued that he was not from Genoa, but from the Aragon region of Spain or from Portugal. These competing hypotheses have been discounted by most scholars.

In 1473, Columbus began his apprenticeship as business agent for the wealthy Spinola, Centurione, and Di Negro families of Genoa. Later, he made a trip to the Greek island Chios in the Aegean Sea, then ruled by Genoa. In May 1476, he took part in an armed convoy sent by Genoa to carry valuable cargo to northern Europe. He probably visited Bristol, England, and Galway, Ireland, where he may have visited St. Nicholas' Collegiate Church. It has been speculated he went to Iceland in 1477, though many scholars doubt this. It is known that in the autumn of 1477, he sailed on a Portuguese ship from Galway to Lisbon, where he found his brother Bartholomew, and they continued trading for the Centurione family. Columbus based himself in Lisbon from 1477 to 1485. In 1478, the Centuriones sent Columbus on a sugar-buying trip to Madeira. He married Felipa Perestrello e Moniz, daughter of Bartolomeu Perestrello, a Portuguese nobleman of Lombard origin, who had been the donatary captain of Porto Santo.

In 1479 or 1480, Columbus's son Diego was born. Between 1482 and 1485, Columbus traded along the coasts of West Africa, reaching the Portuguese trading post of Elmina at the Guinea coast in present-day Ghana. Before 1484, Columbus returned to Porto Santo to find that his wife had died. He returned to Portugal to settle her estate and take Diego with him.

He left Portugal for Castile in 1485, where he took a mistress in 1487, a 20-year-old orphan named Beatriz Enríquez de Arana. It is likely that Beatriz met Columbus when he was in Córdoba, a gathering place for Genoese merchants and where the court of the Catholic Monarchs was located at intervals. Beatriz, unmarried at the time, gave birth to Columbus's second son, Fernando Columbus, in July 1488, named for the monarch of Aragon. Columbus recognized the boy as his offspring. Columbus entrusted his older, legitimate son Diego to take care of Beatriz and pay the pension set aside for her following his death, but Diego was negligent in his duties.

Columbus learned Latin, Portuguese, and Castilian. He read widely about astronomy, geography, and history, including the works of Ptolemy, Pierre d'Ailly's Imago Mundi, the travels of Marco Polo and Sir John Mandeville, Pliny's Natural History, and Pope Pius II's Historia rerum ubique gestarum. According to historian Edmund Morgan,

Columbus was not a scholarly man. Yet he studied these books, made hundreds of marginal notations in them and came out with ideas about the world that were characteristically simple and strong and sometimes wrong ...

Under the Mongol Empire's hegemony over Asia and the Pax Mongolica, Europeans had long enjoyed a safe land passage on the Silk Road to India, parts of East Asia, including China and Maritime Southeast Asia, which were sources of valuable goods. With the fall of Constantinople to the Ottoman Empire in 1453, the Silk Road was closed to Christian traders.

In 1474, the Florentine astronomer Paolo dal Pozzo Toscanelli suggested to King Afonso V of Portugal that sailing west across the Atlantic would be a quicker way to reach the Maluku (Spice) Islands, China, Japan and India than the route around Africa, but Afonso rejected his proposal. In the 1480s, Columbus and his brother proposed a plan to reach the East Indies by sailing west. Columbus supposedly wrote to Toscanelli in 1481 and received encouragement, along with a copy of a map the astronomer had sent Afonso implying that a westward route to Asia was possible. Columbus's plans were complicated by Bartolomeu Dias's rounding of the Cape of Good Hope in 1488, which suggested the Cape Route around Africa to Asia.

Columbus had to wait until 1492 for King Ferdinand and Queen Isabella of Spain to support his voyage across the Atlantic to find gold, spices, a safer route to the East, and converts to Christianity.

Carol Delaney and other commentators have argued that Columbus was a Christian millennialist and apocalypticist and that these beliefs motivated his quest for Asia in a variety of ways. Columbus often wrote about seeking gold in the log books of his voyages and writes about acquiring it "in such quantity that the sovereigns... will undertake and prepare to go conquer the Holy Sepulcher" in a fulfillment of Biblical prophecy. Columbus often wrote about converting all races to Christianity. Abbas Hamandi argues that Columbus was motivated by the hope of "[delivering] Jerusalem from Muslim hands" by "using the resources of newly discovered lands".

Despite a popular misconception to the contrary, nearly all educated Westerners of Columbus's time knew that the Earth is spherical, a concept that had been understood since antiquity. The techniques of celestial navigation, which uses the position of the Sun and the stars in the sky, had long been in use by astronomers and were beginning to be implemented by mariners.

However Columbus made several errors in calculating the size of the Earth, the distance the continent extended to the east, and therefore the distance to the west to reach his goal.

First, as far back as the 3rd century BC, Eratosthenes had correctly computed the circumference of the Earth by using simple geometry and studying the shadows cast by objects at two remote locations. In the 1st century BC, Posidonius confirmed Eratosthenes's results by comparing stellar observations at two separate locations. These measurements were widely known among scholars, but Ptolemy's use of the smaller, old-fashioned units of distance led Columbus to underestimate the size of the Earth by about a third.

Second, three cosmographical parameters determined the bounds of Columbus's enterprise: the distance across the ocean between Europe and Asia, which depended on the extent of the oikumene, i.e., the Eurasian land-mass stretching east–west between Spain and China; the circumference of the Earth; and the number of miles or leagues in a degree of longitude, which was possible to deduce from the theory of the relationship between the size of the surfaces of water and the land as held by the followers of Aristotle in medieval times.

From Pierre d'Ailly's Imago Mundi (1410), Columbus learned of Alfraganus's estimate that a degree of latitude (equal to approximately a degree of longitude along the equator) spanned 56.67 Arabic miles (equivalent to 66.2 nautical miles, 122.6 kilometers or 76.2 mi), but he did not realize that this was expressed in the Arabic mile (about 1,830 meters or 1.14 mi) rather than the shorter Roman mile (about 1,480 m) with which he was familiar. Columbus therefore estimated the size of the Earth to be about 75% of Eratosthenes's calculation.

Third, most scholars of the time accepted Ptolemy's estimate that Eurasia spanned 180° longitude, rather than the actual 130° (to the Chinese mainland) or 150° (to Japan at the latitude of Spain). Columbus believed an even higher estimate, leaving a smaller percentage for water. In d'Ailly's Imago Mundi, Columbus read Marinus of Tyre's estimate that the longitudinal span of Eurasia was 225° at the latitude of Rhodes. Some historians, such as Samuel Eliot Morison, have suggested that he followed the statement in the apocryphal book 2 Esdras (6:42) that "six parts [of the globe] are habitable and the seventh is covered with water." He was also aware of Marco Polo's claim that Japan (which he called "Cipangu") was some 2,414 km (1,500 mi) to the east of China ("Cathay"), and closer to the equator than it is. He was influenced by Toscanelli's idea that there were inhabited islands even farther to the east than Japan, including the mythical Antillia, which he thought might lie not much farther to the west than the Azores, and the distance westward from the Canary Islands to the Indies as only 68 degrees, equivalent to 3,080 nmi (5,700 km; 3,540 mi) (a 58% error).

Based on his sources, Columbus estimated a distance of 2,400 nmi (4,400 km; 2,800 mi) from the Canary Islands west to Japan; the actual distance is 10,600 nmi (19,600 km; 12,200 mi). No ship in the 15th century could have carried enough food and fresh water for such a long voyage, and the dangers involved in navigating through the uncharted ocean would have been formidable. Most European navigators reasonably concluded that a westward voyage from Europe to Asia was unfeasible. The Catholic Monarchs, however, having completed the Reconquista, an expensive war against the Moors in the Iberian Peninsula, were eager to obtain a competitive edge over other European countries in the quest for trade with the Indies. Columbus's project, though far-fetched, held the promise of such an advantage.

Though Columbus was wrong about the number of degrees of longitude that separated Europe from the Far East and about the distance that each degree represented, he did take advantage of the trade winds, which would prove to be the key to his successful navigation of the Atlantic Ocean. He planned to first sail to the Canary Islands before continuing west with the northeast trade wind. Part of the return to Spain would require traveling against the wind using an arduous sailing technique called beating, during which progress is made very slowly. To effectively make the return voyage, Columbus would need to follow the curving trade winds northeastward to the middle latitudes of the North Atlantic, where he would be able to catch the "westerlies" that blow eastward to the coast of Western Europe.

The navigational technique for travel in the Atlantic appears to have been exploited first by the Portuguese, who referred to it as the volta do mar ('turn of the sea'). Through his marriage to his first wife, Felipa Perestrello, Columbus had access to the nautical charts and logs that had belonged to her deceased father, Bartolomeu Perestrello, who had served as a captain in the Portuguese navy under Prince Henry the Navigator. In the mapmaking shop where he worked with his brother Bartholomew, Columbus also had ample opportunity to hear the stories of old seamen about their voyages to the western seas, but his knowledge of the Atlantic wind patterns was still imperfect at the time of his first voyage. By sailing due west from the Canary Islands during hurricane season, skirting the so-called horse latitudes of the mid-Atlantic, he risked being becalmed and running into a tropical cyclone, both of which he avoided by chance.

By about 1484, Columbus proposed his planned voyage to King John II of Portugal. The king submitted Columbus's proposal to his advisors, who rejected it, correctly, on the grounds that Columbus's estimate for a voyage of 2,400 nmi was only a quarter of what it should have been. In 1488, Columbus again appealed to the court of Portugal, and John II again granted him an audience. That meeting also proved unsuccessful, in part because not long afterwards Bartolomeu Dias returned to Portugal with news of his successful rounding of the southern tip of Africa (near the Cape of Good Hope).

Columbus sought an audience with the monarchs Ferdinand II of Aragon and Isabella I of Castile, who had united several kingdoms in the Iberian Peninsula by marrying and now ruled together. On 1 May 1486, permission having been granted, Columbus presented his plans to Queen Isabella, who, in turn, referred it to a committee. The learned men of Spain, like their counterparts in Portugal, replied that Columbus had grossly underestimated the distance to Asia. They pronounced the idea impractical and advised the Catholic Monarchs to pass on the proposed venture. To keep Columbus from taking his ideas elsewhere, and perhaps to keep their options open, the sovereigns gave him an allowance, totaling about 14,000 maravedis for the year, or about the annual salary of a sailor. In May 1489, the queen sent him another 10,000 maravedis, and the same year the monarchs furnished him with a letter ordering all cities and towns under their dominion to provide him food and lodging at no cost.

Columbus also dispatched his brother Bartholomew to the court of Henry VII of England to inquire whether the English crown might sponsor his expedition, but he was captured by pirates en route, and only arrived in early 1491. By that time, Columbus had retreated to La Rábida Friary, where the Spanish crown sent him 20,000 maravedis to buy new clothes and instructions to return to the Spanish court for renewed discussions.

Columbus waited at King Ferdinand's camp until Ferdinand and Isabella conquered Granada, the last Muslim stronghold on the Iberian Peninsula, in January 1492. A council led by Isabella's confessor, Hernando de Talavera, found Columbus's proposal to reach the Indies implausible. Columbus had left for France when Ferdinand intervened, first sending Talavera and Bishop Diego Deza to appeal to the queen. Isabella was finally convinced by the king's clerk Luis de Santángel, who argued that Columbus would take his ideas elsewhere, and offered to help arrange the funding. Isabella then sent a royal guard to fetch Columbus, who had traveled 2 leagues (over 10 km) toward Córdoba.

In the April 1492 "Capitulations of Santa Fe", King Ferdinand and Queen Isabella promised Columbus that if he succeeded he would be given the rank of Admiral of the Ocean Sea and appointed Viceroy and Governor of all the new lands he might claim for Spain. He had the right to nominate three persons, from whom the sovereigns would choose one, for any office in the new lands. He would be entitled to 10% (diezmo) of all the revenues from the new lands in perpetuity. He also would have the option of buying one-eighth interest in any commercial venture in the new lands, and receive one-eighth (ochavo) of the profits.

In 1500, during his third voyage to the Americas, Columbus was arrested and dismissed from his posts. He and his sons, Diego and Fernando, then conducted a lengthy series of court cases against the Castilian crown, known as the pleitos colombinos, alleging that the Crown had illegally reneged on its contractual obligations to Columbus and his heirs. The Columbus family had some success in their first litigation, as a judgment of 1511 confirmed Diego's position as viceroy but reduced his powers. Diego resumed litigation in 1512, which lasted until 1536, and further disputes initiated by heirs continued until 1790.

Between 1492 and 1504, Columbus completed four round-trip voyages between Spain and the Americas, each voyage being sponsored by the Crown of Castile. On his first voyage he reached the Americas, initiating the European exploration and colonization of the continent, as well as the Columbian exchange. His role in history is thus important to the Age of Discovery, Western history, and human history writ large.

In Columbus's letter on the first voyage, published following his first return to Spain, he claimed that he had reached Asia, as previously described by Marco Polo and other Europeans. Over his subsequent voyages, Columbus refused to acknowledge that the lands he visited and claimed for Spain were not part of Asia, in the face of mounting evidence to the contrary. This might explain, in part, why the American continent was named after the Florentine explorer Amerigo Vespucci—who received credit for recognizing it as a "New World"—and not after Columbus.

On the evening of 3 August 1492, Columbus departed from Palos de la Frontera with three ships. The largest was a carrack, the Santa María, owned and captained by Juan de la Cosa, and under Columbus's direct command. The other two were smaller caravels, the Pinta and the Niña, piloted by the Pinzón brothers. Columbus first sailed to the Canary Islands. There he restocked provisions and made repairs then departed from San Sebastián de La Gomera on 6 September, for what turned out to be a five-week voyage across the ocean.

On 7 October, the crew spotted "[i]mmense flocks of birds". On 11 October, Columbus changed the fleet's course to due west, and sailed through the night, believing land was soon to be found. At around 02:00 the following morning, a lookout on the Pinta, Rodrigo de Triana, spotted land. The captain of the Pinta, Martín Alonso Pinzón, verified the sight of land and alerted Columbus. Columbus later maintained that he had already seen a light on the land a few hours earlier, thereby claiming for himself the lifetime pension promised by Ferdinand and Isabella to the first person to sight land. Columbus called this island (in what is now the Bahamas) San Salvador (meaning "Holy Savior"); the natives called it Guanahani. Christopher Columbus's journal entry of 12 October 1492 states:

I saw some who had marks of wounds on their bodies and I made signs to them asking what they were; and they showed me how people from other islands nearby came there and tried to take them, and how they defended themselves; and I believed and believe that they come here from tierra firme to take them captive. They should be good and intelligent servants, for I see that they say very quickly everything that is said to them; and I believe they would become Christians very easily, for it seemed to me that they had no religion. Our Lord pleasing, at the time of my departure I will take six of them from here to Your Highnesses in order that they may learn to speak.

Columbus called the inhabitants of the lands that he visited Los Indios (Spanish for "Indians"). He initially encountered the Lucayan, Taíno, and Arawak peoples. Noting their gold ear ornaments, Columbus took some of the Arawaks prisoner and insisted that they guide him to the source of the gold. Columbus did not believe he needed to create a fortified outpost, writing, "the people here are simple in war-like matters ... I could conquer the whole of them with fifty men, and govern them as I pleased." The Taínos told Columbus that another indigenous tribe, the Caribs, were fierce warriors and cannibals, who made frequent raids on the Taínos, often capturing their women, although this may have been a belief perpetuated by the Spaniards to justify enslaving them.

Columbus also explored the northeast coast of Cuba, where he landed on 28 October. On the night of 26 November, Martín Alonso Pinzón took the Pinta on an unauthorized expedition in search of an island called "Babeque" or "Baneque", which the natives had told him was rich in gold. Columbus, for his part, continued to the northern coast of Hispaniola, where he landed on 6 December. There, the Santa María ran aground on 25 December 1492 and had to be abandoned. The wreck was used as a target for cannon fire to impress the native peoples. Columbus was received by the native cacique Guacanagari, who gave him permission to leave some of his men behind. Columbus left 39 men, including the interpreter Luis de Torres, and founded the settlement of La Navidad, in present-day Haiti. Columbus took more natives prisoner and continued his exploration. He kept sailing along the northern coast of Hispaniola with a single ship until he encountered Pinzón and the Pinta on 6 January.

On 13 January 1493, Columbus made his last stop of this voyage in the Americas, in the Bay of Rincón in northeast Hispaniola. There he encountered the Ciguayos, the only natives who offered violent resistance during this voyage. The Ciguayos refused to trade the amount of bows and arrows that Columbus desired; in the ensuing clash one Ciguayo was stabbed in the buttocks and another wounded with an arrow in his chest. Because of these events, Columbus called the inlet the Golfo de Las Flechas (Bay of Arrows).

Columbus headed for Spain on the Niña, but a storm separated him from the Pinta, and forced the Niña to stop at the island of Santa Maria in the Azores. Half of his crew went ashore to say prayers of thanksgiving in a chapel for having survived the storm. But while praying, they were imprisoned by the governor of the island, ostensibly on suspicion of being pirates. After a two-day standoff, the prisoners were released, and Columbus again set sail for Spain.

Another storm forced Columbus into the port at Lisbon. From there he went to Vale do Paraíso north of Lisbon to meet King John II of Portugal, who told Columbus that he believed the voyage to be in violation of the 1479 Treaty of Alcáçovas. After spending more than a week in Portugal, Columbus set sail for Spain. Returning to Palos on 15 March 1493, he was given a hero's welcome and soon afterward received by Isabella and Ferdinand in Barcelona. To them he presented kidnapped Taínos and various plants and items he had collected.

Columbus's letter on the first voyage, probably dispatched to the Spanish court upon arrival in Lisbon, was instrumental in spreading the news throughout Europe about his voyage. Almost immediately after his arrival in Spain, printed versions began to appear, and word of his voyage spread rapidly. Most people initially believed that he had reached Asia. The Bulls of Donation, three papal bulls of Pope Alexander VI delivered in 1493, purported to grant overseas territories to Portugal and the Catholic Monarchs of Spain. They were replaced by the Treaty of Tordesillas of 1494.

The two earliest published copies of Columbus's letter on the first voyage aboard the Niña were donated in 2017 by the Jay I. Kislak Foundation to the University of Miami library in Coral Gables, Florida, where they are housed.

On 24 September 1493, Columbus sailed from Cádiz with 17 ships, and supplies to establish permanent colonies in the Americas. He sailed with nearly 1,500 men, including sailors, soldiers, priests, carpenters, stonemasons, metalworkers, and farmers. Among the expedition members were Alvarez Chanca, a physician who wrote a detailed account of the second voyage; Juan Ponce de León, the first governor of Puerto Rico and Florida; the father of Bartolomé de las Casas; Juan de la Cosa, a cartographer who is credited with making the first world map depicting the New World; and Columbus's youngest brother Diego. The fleet stopped at the Canary Islands to take on more supplies, and set sail again on 7 October, deliberately taking a more southerly course than on the first voyage.

On 3 November, they arrived in the Windward Islands; the first island they encountered was named Dominica by Columbus, but not finding a good harbor there, they anchored off a nearby smaller island, which he named Mariagalante, now a part of Guadeloupe and called Marie-Galante. Other islands named by Columbus on this voyage were Montserrat, Antigua, Saint Martin, the Virgin Islands, as well as many others.

On 17 November, Columbus first sighted the eastern coast of the island of Puerto Rico, known to its native Taino people as Borikén. His fleet sailed along the island's southern coast for a whole day, before making landfall on its northwestern coast at the Bay of Añasco, early on 19 November. Upon landing, Columbus christened the island San Juan Bautista after John the Baptist, and remained anchored there for two days from 20 to 21 November, filling the water casks of the ships in his fleet.

On 22 November, Columbus returned to Hispaniola to visit La Navidad in modern-day Haiti, where 39 Spaniards had been left during the first voyage. Columbus found the fort in ruins. He learned from Guacanagaríx, the local tribe leader, that his men had quarreled over gold and taken women from the tribe, and that after some left for the territory of Caonabo, Caonabo came and burned the fort and killed the rest of the men there.

Columbus then established a poorly located and short-lived settlement to the east, La Isabela, in the present-day Dominican Republic. By the end of 1494, disease and famine had killed two-thirds of the Spanish settlers there.

From April to August 1494, Columbus explored Cuba and Jamaica, then returned to Hispaniola. Before leaving on this exploration to Cuba, Columbus had ordered a large amount of men, under Pedro Margarit, to "journey the length and breadth of the island, enforcing Spanish control and bringing all the people under the Spanish yoke." These men, in his absence, raped women, took men captive to be servants, and stole from the indigenous people. A number of Spanish were killed in retaliation. By the time Columbus returned from exploring Cuba, the four primary leaders of the Arawak people in Hispaniola were gathering for war to try to drive the Spanish from the Island. Columbus assembled a large number of troops, and joined with his one native ally, chief [Guacanagarix], met for battle. The Spanish, even though they were largely outnumbered, won this battle, and over the next 9 months Columbus continued to wage war on the native Taino on Hispaniola until they surrendered and agreed to pay tribute.

Columbus implemented encomienda, a Spanish labor system that rewarded conquerors with the labor of conquered non-Christian people. It is also recorded that punishments to both Spaniards and natives included whippings and mutilation (cutting noses and ears).

Columbus and the colonists enslaved many of the indigenous people, including children. Natives were beaten, raped, and tortured for the location of imagined gold. Thousands committed suicide rather than face the oppression.

In February 1495, Columbus rounded up about 1,500 Arawaks, some of whom had rebelled, in a great slave raid. About 500 of the strongest were shipped to Spain as slaves, with about two hundred of those dying en route.

In June 1495, the Spanish crown sent ships and supplies to Hispaniola. In October, Florentine merchant Gianotto Berardi, who had won the contract to provision the fleet of Columbus's second voyage and to supply the colony on Hispaniola, received almost 40,000 maravedís worth of enslaved Indians. He renewed his effort to get supplies to Columbus, and was working to organize a fleet when he suddenly died in December. On 10 March 1496, having been away about 30 months, the fleet departed La Isabela. On 8 June the crew sighted land somewhere between Lisbon and Cape St. Vincent, and disembarked in Cádiz on 11 June.

On 30 May 1498, Columbus left with six ships from Sanlúcar, Spain. The fleet called at Madeira and the Canary Islands, where it divided in two, with three ships heading for Hispaniola and the other three vessels, commanded by Columbus, sailing south to the Cape Verde Islands and then westward across the Atlantic. It is probable that this expedition was intended at least partly to confirm rumors of a large continent south of the Caribbean Sea, that is, South America.

On 31 July they sighted Trinidad, the most southerly of the Caribbean islands. On 5 August, Columbus sent several small boats ashore on the southern side of the Paria Peninsula in what is now Venezuela, near the mouth of the Orinoco river. This was the first recorded landing of Europeans on the mainland of South America, which Columbus realized must be a continent. The fleet then sailed to the islands of Chacachacare and Margarita, reaching the latter on 14 August, and sighted Tobago and Grenada from afar, according to some scholars.

On 19 August, Columbus returned to Hispaniola. There he found settlers in rebellion against his rule, and his unfulfilled promises of riches. Columbus had some of the Europeans tried for their disobedience; at least one rebel leader was hanged.

In October 1499, Columbus sent two ships to Spain, asking the Court of Spain to appoint a royal commissioner to help him govern. By this time, accusations of tyranny and incompetence on the part of Columbus had also reached the Court. The sovereigns sent Francisco de Bobadilla, a relative of Marquesa Beatriz de Bobadilla, a patron of Columbus and a close friend of Queen Isabella, to investigate the accusations of brutality made against the Admiral. Arriving in Santo Domingo while Columbus was away, Bobadilla was immediately met with complaints about all three Columbus brothers. He moved into Columbus's house and seized his property, took depositions from the Admiral's enemies, and declared himself governor.

Bobadilla reported to Spain that Columbus once punished a man found guilty of stealing corn by having his ears and nose cut off and then selling him into slavery. He claimed that Columbus regularly used torture and mutilation to govern Hispaniola. Testimony recorded in the report stated that Columbus congratulated his brother Bartholomew on "defending the family" when the latter ordered for a woman to be paraded naked through the streets and then had her tongue cut because she had "spoken ill of the admiral and his brothers". The document also describes how Columbus put down native unrest and revolt: he first ordered a brutal suppression of the uprising in which many natives were killed, and then paraded their dismembered bodies through the streets in an attempt to discourage further rebellion. Columbus vehemently denied the charges. The neutrality and accuracy of the accusations and investigations of Bobadilla toward Columbus and his brothers have been disputed by historians, given the anti-Italian sentiment of the Spaniards and Bobadilla's desire to take over Columbus's position.

In early October 1500, Columbus and Diego presented themselves to Bobadilla, and were put in chains aboard La Gorda, the caravel on which Bobadilla had arrived at Santo Domingo. They were returned to Spain, and languished in jail for six weeks before King Ferdinand ordered their release. Not long after, the king and queen summoned the Columbus brothers to the Alhambra palace in Granada. The sovereigns expressed indignation at the actions of Bobadilla, who was then recalled and ordered to make restitutions of the property he had confiscated from Columbus. The royal couple heard the brothers' pleas; restored their freedom and wealth; and, after much persuasion, agreed to fund Columbus's fourth voyage. However, Nicolás de Ovando was to replace Bobadilla and be the new governor of the West Indies.

New light was shed on the seizure of Columbus and his brother Bartholomew, the Adelantado, with the discovery by archivist Isabel Aguirre of an incomplete copy of the testimonies against them gathered by Francisco de Bobadilla at Santo Domingo in 1500. She found a manuscript copy of this pesquisa (inquiry) ‌in the Archive of Simancas, Spain, uncatalogued until she and Consuelo Varela published their book, La caída de Cristóbal Colón: el juicio de Bobadilla (The fall of Christopher Colón: the judgement of Bobadilla) in 2006.

On 9 May 1502, Columbus left Cádiz with his flagship Santa María and three other vessels. The ships were crewed by 140 men, including his brother Bartholomew as second in command and his son Fernando. He sailed to Asilah on the Moroccan coast to rescue Portuguese soldiers said to be besieged by the Moors. The siege had been lifted by the time they arrived, so the Spaniards stayed only a day and continued on to the Canary Islands.

On 15 June, the fleet arrived at Martinique, where it lingered for several days. A hurricane was forming, so Columbus continued westward, hoping to find shelter on Hispaniola. He arrived at Santo Domingo on 29 June, but was denied port, and the new governor Francisco de Bobadilla refused to listen to his warning that a hurricane was approaching. Instead, while Columbus's ships sheltered at the mouth of the Rio Jaina, the first Spanish treasure fleet sailed into the hurricane. Columbus's ships survived with only minor damage, while 20 of the 30 ships in the governor's fleet were lost along with 500 lives (including that of Francisco de Bobadilla). Although a few surviving ships managed to straggle back to Santo Domingo, Aguja, the fragile ship carrying Columbus's personal belongings and his 4,000 pesos in gold was the sole vessel to reach Spain. The gold was his tenth (décimo) of the profits from Hispaniola, equal to 240,000 maravedis, guaranteed by the Catholic Monarchs in 1492.

After a brief stop at Jamaica, Columbus sailed to Central America, arriving at the coast of Honduras on 30 July. Here Bartholomew found native merchants and a large canoe. On 14 August, Columbus landed on the continental mainland at Punta Caxinas, now Puerto Castilla, Honduras. He spent two months exploring the coasts of Honduras, Nicaragua, and Costa Rica, seeking a strait in the western Caribbean through which he could sail to the Indian Ocean. Sailing south along the Nicaraguan coast, he found a channel that led into Almirante Bay in Panama on 5 October.

As soon as his ships anchored in Almirante Bay, Columbus encountered Ngäbe people in canoes who were wearing gold ornaments. In January 1503, he established a garrison at the mouth of the Belén River. Columbus left for Hispaniola on 16 April. On 10 May he sighted the Cayman Islands, naming them "Las Tortugas" after the numerous sea turtles there. His ships sustained damage in a storm off the coast of Cuba. Unable to travel farther, on 25 June 1503 they were beached in Saint Ann Parish, Jamaica.

For six months Columbus and 230 of his men remained stranded on Jamaica. Diego Méndez de Segura, who had shipped out as a personal secretary to Columbus, and a Spanish shipmate called Bartolomé Flisco, along with six natives, paddled a canoe to get help from Hispaniola. The governor, Nicolás de Ovando y Cáceres, detested Columbus and obstructed all efforts to rescue him and his men. In the meantime Columbus, in a desperate effort to induce the natives to continue provisioning him and his hungry men, won their favor by predicting a lunar eclipse for 29 February 1504, using Abraham Zacuto's astronomical charts. Despite the governor's obstruction, Christopher Columbus and his men were rescued on 28 June 1504, and arrived in Sanlúcar, Spain, on 7 November.

Columbus had always claimed that the conversion of non-believers was one reason for his explorations, and he grew increasingly religious in his later years. Probably with the assistance of his son Diego and his friend the Carthusian monk Gaspar Gorricio, Columbus produced two books during his later years: a Book of Privileges (1502), detailing and documenting the rewards from the Spanish Crown to which he believed he and his heirs were entitled, and a Book of Prophecies (1505), in which passages from the Bible were used to place his achievements as an explorer in the context of Christian eschatology.

In his later years, Columbus demanded that the Crown of Castile give him his tenth of all the riches and trade goods yielded by the new lands, as stipulated in the Capitulations of Santa Fe. Because he had been relieved of his duties as governor, the Crown did not feel bound by that contract and his demands were rejected. After his death, his heirs sued the Crown for a part of the profits from trade with America, as well as other rewards. This led to a protracted series of legal disputes known as the pleitos colombinos ("Columbian lawsuits").

During a violent storm on his first return voyage, Columbus, then 41, had suffered an attack of what was believed at the time to be gout. In subsequent years, he was plagued with what was thought to be influenza and other fevers, bleeding from the eyes, temporary blindness and prolonged attacks of gout. The attacks increased in duration and severity, sometimes leaving Columbus bedridden for months at a time, and culminated in his death 14 years later.

Based on Columbus's lifestyle and the described symptoms, some modern commentators suspect that he suffered from reactive arthritis, rather than gout. Reactive arthritis is a joint inflammation caused by intestinal bacterial infections or after acquiring certain sexually transmitted diseases (primarily chlamydia or gonorrhea). In 2006, Frank C. Arnett, a medical doctor, and historian Charles Merrill, published their paper in The American Journal of the Medical Sciences proposing that Columbus had a form of reactive arthritis; Merrill made the case in that same paper that Columbus was the son of Catalans and his mother possibly a member of a prominent converso (converted Jew) family. "It seems likely that [Columbus] acquired reactive arthritis from food poisoning on one of his ocean voyages because of poor sanitation and improper food preparation", says Arnett, a rheumatologist and professor of internal medicine, pathology and laboratory medicine at the University of Texas Medical School at Houston.

Some historians such as H. Micheal Tarver and Emily Slape, as well as medical doctors such as Arnett and Antonio Rodríguez Cuartero, believe that Columbus had such a form of reactive arthritis, but according to other authorities, this is "speculative", or "very speculative".

After his arrival to Sanlúcar from his fourth voyage (and Queen Isabella's death), an ill Columbus settled in Seville in April 1505. He stubbornly continued to make pleas to the Crown to defend his own personal privileges and his family's. He moved to Segovia (where the court was at the time) on a mule by early 1506, and, on the occasion of the wedding of King Ferdinand with Germaine of Foix in Valladolid, Spain, in March 1506, Columbus moved to that city to persist with his demands. On 20 May 1506, aged 54, Columbus died in Valladolid.