San Sebastián de La Gomera is the capital and a municipality of La Gomera in the Canary Islands, Spain. It also hosts the main harbour. The population was 9,584 in 2023, and the area is 113.59 square kilometres (43.86 sq mi).

The port serves ferry routes to the islands of Tenerife, La Palma and El Hierro. Streets include Calle Real and F. Olsen. A bus station named Estación de Guaguas is used for bus lines throughout the island; it is located on Avenida Del Quinto Centenario.

On 6 September, 1492, Christopher Columbus, having restocked his provisions and made repairs, departed from San Sebastián de La Gomera on his first expedition to what he thought were the Indies not knowing that the Americas were what he eventually discovered.

• Ignacio Lorenzo de Armas (born 1706), settler and mayor of San Antonio, Texas in 1738 and 1764.

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  San Sebastián de La Gomera
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  Torre del conde
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  Church Iglesia de La Asunción
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  Roque de Agando
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  The big Fred. Olsen Express ferry
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  Old and new in San Sebastian
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  Old windmill in San Sebastian

• List of municipalities in Santa Cruz de Tenerife

• Phillips, William D. Jr.; Phillips, Carla Rahn (1992). The Worlds of Christopher Columbus. Cambridge, UK: Cambridge University Press. ISBN 978-0-521-35097-6.

• San Sebastian de La Gomera - Canary Islands Info