The Ezra Yaghoub Synagogue (Persian: کنیسه عزرا یعقوب) is an Orthodox Jewish congregation and synagogue, located in the Old Jewish Quarter, in the Oudlajan neighborhood of Tehran, Iran. Completed in 1895, the synagogue is one of oldest synagogues in Tehran.

The synagogue was established during the reign of Naser al-Din Shah Qajar and was repaired and restored many times since then. The synagogue was completed in 1894–1895 AD (1273 SH) on a 524-square-metre (5,640 sq ft) site. Ezra Yaghoub, for whom the synagogue is named, was a prominent Iranian Jewish merchant and was the first person to make business contact with the city of Manchester in England. After his death, aged forty years, his widow spent most of his fortune on charity for the Iranian Jews.

The building was placed on the list of historic buildings in the Cultural Heritage, Handcrafts and Tourism Organization since 2004–2005  AD (1383 SH). At its peak, the synagogue would have accommodated approximately 200 worshippers.

In 2019, several antique Torah scrolls were stolen from the synagogue.

• History of the Jews in Iran
• List of synagogues in Iran

• Shaoul, Eshagh (2008). "Photo Gallery from May 2008 Visit to Sarechal: Scenes from a Synagogue and a Mosque on the Same Street" (image gallery). Sarechal, 50 Years Later. Retrieved October 8, 2024.

Jewish Quarter