Gmina Perlejewo is a rural gmina (administrative district) in Siemiatycze County, Podlaskie Voivodeship, in north-eastern Poland. Its seat is the village of Perlejewo, which lies approximately 26 kilometres (16 mi) north-west of Siemiatycze and 74 km (46 mi) south-west of the regional capital Białystok.

The gmina covers an area of 106.32 square kilometres (41.1 sq mi), and as of 2006 its total population is 3,149.

Gmina Perlejewo contains the villages and settlements of Borzymy, Czarkówka Duża, Czarkówka Mała, Głęboczek, Głody, Granne, Kobyla, Koski Duże, Koski-Wypychy, Kruzy, Leśniki, Leszczka Duża, Leszczka Mała, Miodusy-Dworaki, Miodusy-Inochy, Miodusy-Pokrzywne, Moczydły-Dubiny, Moczydły-Kukiełki, Moczydły-Pszczółki, Nowe Granne, Olszewo, Osnówka, Osnówka-Wyręby, Pełch, Perlejewo, Pieczyski, Poniaty, Stare Moczydły, Twarogi Lackie, Twarogi Ruskie, Twarogi-Mazury, Twarogi-Trąbnica, Twarogi-Wypychy and Wiktorowo.

Gmina Perlejewo is bordered by the gminas of Ciechanowiec, Drohiczyn, Grodzisk and Jabłonna Lacka.

• Polish official population figures 2006