Manzac-sur-Vern (French pronunciation: [mɑ̃zak syʁ vɛʁn]; Occitan: Manzac de Vern) is a commune in the Dordogne department in Nouvelle-Aquitaine in southwestern France.

There are near the town both prehistoric Gallo-Roman traces. In the Middle Ages, Manzac had a former Priory of the Abbey of Brantôme and in November 27, 1911, the commune of Manzac was renamed Manzac-sur-Vern

• Léonce Cubélier de Beynac (1866-1942), poet.
• Christian Pabœuf (1956- ) composer.
• Valentin Huot (1929-2017) cyclist.

Historical population

Year	Pop.	±%
1962	437	—
1968	401	−8.2%
1975	420	+4.7%
1982	417	−0.7%
1990	488	+17.0%
1999	505	+3.5%
2008	527	+4.4%

Significant landmarks include the Saint-Pierre-ès-links a 15th-century church with façade (shown right) dating from the 19th century and Gothic bell tower.

• Chartreuse de la Faye a listed historical site.
• Leyzarnie Castle, rebuilt in the early 20th century, also a listed historic monuments.
• Tower of the former Castle of the Châtenet.
• Chartreuse of Couture.
• Manor de dives du, from the 17th century.
• Cluzeau à Bencharel.

• Communes of the Dordogne department