Route 80 is a state highway in southeastern Missouri. The route is located in northern New Madrid and central Mississippi Counties.

Route description

Route 80's western terminus is at U.S. Route 61/62 near Matthews, which is located midway between Sikeston and New Madrid, with a junction with I-55 located about a mile (1.6 km) to the east. East Prairie is the only other town on the highway. Its eastern terminus is a dead end at the Mississippi River in Belmont.

History

At Belmont, there used to be a ferry connecting Route 80 to Kentucky Route 80, which is a major east–west thoroughfare across southern Kentucky, continuing into Virginia, as Virginia State Route 80. The toll ferry service was discontinued in 1984.

Major intersections

County	Location	mi	km	Destinations	Notes
New Madrid	​	0.000	0.000	US 61 / US 62 / Route H – Matthews, New Madrid, Sikeston	Western terminus; Eastern terminus of Route H
	​	1.505– 1.596	2.422– 2.569	I-55 – Sikeston, Blytheville, AR	Diamond interchange
	​	1.634	2.630	Route V	Northern terminus of Route V
	​	2.566	4.130	Route AA – Miner	Southern terminus of Route AA
New Madrid–Mississippi county line	​	8.058	12.968	Route B – Bertrand	Southern terminus of Route B
Mississippi	​	10.052	16.177	Route BB	Northern terminus of Route BB
	East Prairie	11.171	17.978	Route 105 – Charleston	Southern terminus of Route 105
	​	13.236	21.301	Route 102 – Charleston
	​	15.263	24.563	Route 75 – Anniston	Southern terminus of Route 75
	​	17.817	28.674	Route AA	Northern terminus of Route AA
	​	21.312	34.298	Route 77 – Wyatt, Wolf Island
	​	27.302	43.938	Belmont–Columbus Ferry	Former ferry, currently a dead end
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Closed/former