Muskogee High School (MHS) is a three-year public high school in Muskogee, Oklahoma, U.S.. It is accredited by the Oklahoma State Department of Education and the Oklahoma Secondary School Activities Association.

Muskogee High School is part of the Muskogee Independent School District No. 20 of Muskogee County, Oklahoma, more commonly known as Muskogee Public Schools.

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In August 2018 the school administration announced that any student who, within a four-week period, is late to classes four times would receive a fine of $250. At the same time, the administration stated that safety concerns caused it to ban students from wandering around the campus during lunch times, increase class times, and reduce the times of lunch periods. According to a KOCO-TV article, students planned to protest the new rules.

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Muskogee High School offers a wide range of academic courses.

The Advanced Placement (AP) Program provides college-level courses to MHS student through AP courses. Through AP Exams, students have the opportunity to earn credit or advanced standing at most of the nation's colleges and universities.

Juniors and seniors of exceptional ability are provided with the opportunity to gain college credit while completing their high school education. School counselors must verify that prerequisites are met and that enrollment in the college course has been completed, including payment for the course(s), prior to concurrent enrollment being changed on a student's schedule.

Muskogee High School provides comprehensive services to qualifying students.

Through different programs at MHS students are allowed to incorporate work experience into their academic plans. The DECA program allows students to attends MHS half the day and maintain a job the other half. Students interested in technical and career-specific skills to prepare for such careers as automotive, child care, computers, construction, cosmetology, industrial technology, health care, and landscape may enroll in programs at the Muskogee Indian Capital Technology Center, affiliated with the Oklahoma Department of Career and Technology Education.

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State championship (Muskogee High): 1975

State Championships (Central High): 1910 – 1914 – 1919 – 1920 – 1923 – 1925 – 1935 – 1940 – 1947 – 1948 – 1949 – 1950 – 1951

State Championship (Muskogee High) : 1986 - 2023

State Championship (Muskogee High) : 1983, 1998, 2000, 2009

The Rougher Softball Team was also named the Class 6A Academic State Champions in 2013, with a team GPA of 3.7.

• Archie Bradley, professional baseball player (transferred to Broken Arrow Senior High School)
• Bo Bolinger – football player
• Kamren Curl – football player
• John Tyler Hammons – former mayor of Muskogee
• George Faught – current State Representative for Muskogee
• Drew Edmondson – former Attorney General of Oklahoma and 2018 Democratic nominee for governor
• Ed Edmondson – former Congressman for Oklahoma's 2nd District
• James E. Edmondson – current Oklahoma Supreme Court justice
• J. Howard Edmondson – former Oklahoma Governor and Senator
• Mike Synar – former Oklahoma Congress from Oklahoma's 2nd District
• Ernest E. Evans – Commander, United States Navy. Died in combat 1944.
• Jack Jacobs – former Canadian Football League quarterback and one of the original inductees to the Canadian Football Hall of Fame.
• Glen D. Johnson, Jr. – current Chancellor of the Oklahoma State System of Higher Education
• Seth Littrell – Former head football coach of North Texas
• Robert Reed – actor.
• Robert Thomas – NFL defensive lineman for the New York Giants
• Stacy McGee - football player
• Kyle McCarter - politician
• Charles Thompson football player, 1986 MVP State Championship Team, Author