North Dakota Highway 22 (ND 22) is a 156.051-mile-long (251.140 km) major north–south state highway in North Dakota. It begins at the South Dakota state line south of the small town of Reeder and ends at ND 23 west of New Town and north of Mandaree. The route has one concurrency with U.S. Route 12 (US 12). The highway widely parallels US 85, running about fifteen miles east of it.

North Dakota Highway 22 begins at the South Dakota state line as a continuation of South Dakota Highway 79. From there it heads north to the town of Reeder. North of Reeder, the route joins U.S. Route 12, heading southeast for two miles. It then heads north, joining with Highway 21 south of New England. Highway 21's concurrency with Highway 22 ends at New England, and Highway 22 continues north to Dickinson, where it has a truck detour around a low railroad bridge before it meets Interstate 94 Bus. Loop and Interstate 94 itself.

ND 22 continues north to meet Highway 200 just south of the city of Killdeer. The highway enters the Badlands 12 miles north of Killdeer and crosses the Little Missouri River switching from Mountain Time to Central Time.

The route continues just west of Mandaree, then meets Highway 73, and finally ends at Highway 23 in an unpopulated area west of Lake Sakakawea and New Town in McKenzie County.

County	Location	mi	km	Destinations	Notes
Harding	​	0.000	0.000	SD 79	Continuation into South Dakota
Adams	Reeder	11.929	19.198	US 12 west – Bowman	Southern end of US 12 concurrency
	​	16.186	26.049	US 12 east – Hettinger	Northern end of US 12 concurrency
Hettinger	​	37.564	60.453	ND 21 east – Mott	Southern end of ND 21 concurrency
	New England	45.619	73.417	ND 21 west	Northern end of ND 21 concurrency
Stark	Dickinson	70.882	114.074	I-94 BL (Villard Street)
		72.057	115.965	I-94 – Medora, Bismarck	I-94 exit 61
Dunn	Killdeer	104.534	168.231	ND 200 east / ND 22 Bus. north – Dunn Center	Southern end of ND 200 concurrency, southern terminus of ND 22B, Roundabout
	​	105.710	170.124	ND 200 west – Watford City	Northern end of ND 200 concurrency, Roundabout
	​	109.518	176.252	ND 22 Bus. south	Northern terminus of ND 22B
McKenzie	​	141.099	227.077	ND 73 west – Watford City	Eastern terminus of ND 73
	​	156.051	251.140	ND 23	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

State Route 22 Business
Location	Killdeer
Length	5.052 mi (8.130 km)

North Dakota Highway 22 Business (ND 22 Bus.) is a 5.052-mile-long (8.130 km) north–south state highway in the U.S. state of North Dakota. ND 22 Bus.'s southern terminus is at ND 22 and ND 200 in Killdeer, and the northern terminus is at ND 22 northwest of Killdeer.

The entire route is in Dunn County.

Location	mi	km	Destinations	Notes
Killdeer	0.000	0.000	ND 22 / ND 200	Southern terminus
​	5.052	8.130	ND 22	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi