Nyzhni Sirohozy Raion (Ukrainian: Нижньосірогозький район) was one of the 18 administrative raions (a district) of Kherson Oblast in southern Ukraine. Its administrative center was located in the urban-type settlement of Nyzhni Sirohozy. The raion was abolished on 18 July 2020 as part of the administrative reform of Ukraine, which reduced the number of raions of Kherson Oblast to five. The area of Nyzhni Sirohozy Raion was merged into Henichesk Raion. The last estimate of the raion population was 15,033 (2020 est.)

At the time of disestablishment, the raion consisted of one hromada, Nyzhni Sirohozy settlement hromada with the administration in Nyzhni Sirohozy.