The Diocese of Fajardo–Humacao(Latin: Dioecesis Faiardensis–Humacaensis) is a Latin Church ecclesiastical territory or diocese of the Catholic Church and consists of part of the east and the northeast of the island of Puerto Rico. The current bishop is Luis Miranda Rivera, who was appointed on May 16, 2020, by Pope Francis. The mother church is Cathedral Santiago Apóstol in Fajardo, Puerto Rico.

The See of Fajardo–Humacao was canonically erected on May 11, 2008, and is a suffragan diocese of the Metropolitan Province of San Juan de Puerto Rico. Its jurisdiction includes the municipalities of Loíza, Canóvanas, Río Grande, Luquillo, Fajardo, Ceiba, Naguabo, Humacao, Culebra, and Vieques.

The list of the Bishops of Fajardo–Humacao (Latin rite) and their tenures of service:

1. Eusebio Ramos Morales (March 11, 2008 – February 2, 2017), appointed Bishop of Caguas
2. Luis Miranda Rivera, O. Carm. (Appointed on May 16, 2020; Consecrated and installed on August 15, 2020)

On 7 September 2018, Judge Edward Godoy ruled that the bankruptcy filed by the Archdiocese of San Juan would also apply to every Catholic diocese in Puerto Rico, including Fajardo-Humacao, and that all would now have their assets protected under Chapter 11.