The Diocese of Mayagüez (Latin: Dioecesis Maiaguezensis) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in the United States and consists of the western part of the island of Puerto Rico, an American commonwealth. The diocese is led by a prelate bishop, who pastors the motherchurch in the City of Mayagüez, Catedral Nuestra Señora de la Candelaria in front of the Plaza Colón.

The See of Mayagüez was canonically erected on March 1, 1976, and is a suffragan diocese of the Metropolitan Province of San Juan de Puerto Rico. The Diocese is subdivided into 29 Parishes: 17 originally located at the Diocese of Ponce, eight formerly at the Diocese of Arecibo, and four new parishes. Its jurisdiction includes the municipalities of Aguadilla, Rincón, Aguada, Moca, San Sebastián, Añasco, Mayagüez, Las Marías, Maricao, Hormigueros, Cabo Rojo, San Germán, and Sabana Grande.

As of July, 2011 the bishop of the See of Mayagüez was Alvaro Corrada del Rio, SJ. He retired on May 9, 2020, and Ángel Luis Ríos Matos was appointed at that time to succeed him.

The list of the Bishops of Mayagüez (Latin rite) and their tenures of service:

1. Bishop Ulises Aurelio Casiano Vargas (March 4, 1976 – July 6, 2011)
2. Bishop Alvaro Corrada del Rio, S.J. (July 6, 2011 – May 9, 2020)
3. Bishop Ángel Luis Ríos Matos (August 1, 2020 - )

• Colegio San Agustin, Cabo Rojo, Grades: PK-12
• Colegio San Benito, Mayagüez, Grades PK-12
• Colegio San Carlos, Aguadilla, Grades: PK-12 (Closed)
• Academia Inmaculada Concepcion Elemental, Mayaguez, Grades: PK-6
• Academia Inmaculada Concepcion - Superior, Mayagüez, Grades: 7-12
• Colegio San José, San German, Grades: K-12
• Academia San Luis, Lajas, Grades: K-12
• Colegio La Milagrosa, Mayagüez, Grades:PK-12
• Academia San Sebastian Martir, Grades: K-9
• Academia Santa Rosa de Lima, Rincón, Grades PK-6 (closed around 2000).
• Colegio Nuestra Señora de la Monserrate, Moca, Grades PK-8
• Escuela Catolica de la Salle, Añasco, Grades: 1-9
• Colegio San Agustin y Espiritu Santo, Sabana Grande, Grades: Pre-PreK-8

By the year 2004 its population consisted of 491,518 people, of which 376,000 were baptized, being 76.5% of the total population.

Year	Population			Priests				Deacons	Religious		Parishes
	baptised	total	%	number	secular	regular	baptised per priest		men	women
1976	352.356	?	?	56	21	35	6.292		4	105	25
1980	374.000	469.000	79,7	66	21	45	5.666		54	115	25
1990	426.000	519.000	82,1	74	40	34	5.756	2	39	149	29
1999	360.000	491.518	73,2	77	47	30	4.675	3	32	143	58
2000	360.000	491.518	73,2	71	41	30	5.070	3	32	135	58
2001	360.000	491.518	73,2	70	40	30	5.142	3	32	134	58
2002	360.000	491.518	73,2	68	38	30	5.294	4	32	133	58
2003	376.000	491.518	76,5	67	37	30	5.611	4	32	133	29
2004	376.000	491.518	76,5	70	40	30	5.371	4	32	114	29

On 7 September 2018, Judge Edward Godoy ruled that the bankruptcy filed by the Archdiocese of San Juan would also apply to every Catholic diocese in Puerto Rico, including Mayagüez, and that all would now have their assets protected under Chapter 11.

• Diócesis de Mayagüez (Official Site in Spanish)
• Roman Catholic Diocese of Mayagüez GCatholic.org website
• Old Official Site of the Diocese in Spanish Archived 2009-03-11 at the Wayback Machine (defunct)
• Diocese of Mayagüez YouTube Channel run by Medios de Comunicación Social - Diócesis de Mayagüez (Social Communication Media Productions of the Diocese of Mayagüez) (PRODIOMA) (Official Site in Spanish)

18°12′04″N 67°08′18″W / 18.2011°N 67.1383°W / 18.2011; -67.1383