Prignano Cilento is a town and comune in the province of Salerno in the Campania region of south-western Italy. As of 2017 its population was of 1,035.

Prignano is located in northern Cilento and borders with the municipalities of Agropoli (10 km west), Cicerale, Ogliastro Cilento (4 km north), Perito, Rutino and Torchiara. In the eastern edge of its territory is located the Alento River dam and reservoir, shared with Perito and Cicerale municipal territories.

It counts the hamlets of (frazioni) Melito and San Giuliano; and the rural localities of Acquabona, Alento, Selva and Serre. Until the end of the 16th century, it existed another hamlet named Poglisi (or Puglisi).

• Melito lies under the hill where Prignano (1 km far) is located. It is a rural medieval village and its main sights are the Tower Volpe, the Old Fountain and St. Catherine's Chapel.
• San Giuliano is urbanistically contiguous to Prignano and is nowadays considered a quarter of it. Anciently known as Taverna, it was a post house, and its main sight is St. Julian's Chapel.

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Notable churches in the town are San Nicola di Bari, Santa Caterina, San Cosmo e Damiano, Sant'Antonio and San Biagio (originally the church of San Giuliano). There are 4 private antique chapels in the town. There was an Italo-Greek monastery, Santa Sofia, in the locality of Serre.

The town is crossed in the middle by the state highway SS18, and is served by the SS18 Var highway, linking Salerno to Sapri (via Battipaglia, Agropoli and Vallo della Lucania), at the homonym exit. Nearest railway stations are Torchiara and Agropoli-Castellabate, both on the Southern Tyrrhenian railway.

• Cilentan dialect
• Cilento and Vallo di Diano National Park

• (in Italian) Prignano Cilento official website
• Prignano Cilento on tuttocitta.it