Sasso d'Ombrone is a village in Tuscany, central Italy, administratively a frazione of the comune of Cinigiano, province of Grosseto. At the time of the 2001 census its population amounted to 300.

Sasso d'Ombrone is about 33 km from Grosseto and 8 km from Cinigiano, and it is situated along the road which links Cinigiano to the Cipressino Provincial Road at Paganico, on a hill in the valley of Ombrone.

Formerly known as Sasso di Maremma, the village was born in the 13th century as a castle of the Aldobrandeschi. It was then held by the Ardengheschi and conquered by the Republic of Siena in the 15th century.

• Church of San Michele Arcangelo (13th century), main parish church of the village, it was re-built in the 16th century and then in the early 19th century.
• Sanctuary of Madonna del Soccorso (16th century), it was entirely re-built in 1872.
• Castle of Sasso (13th century), it's now in ruins.

• (in Italian) Emanuele Repetti, «Sasso d'Ombrone», Dizionario Geografico Fisico Storico della Toscana, 1833–1846.
• Bruno Santi, Guida storico-artistica alla Maremma. Itinerari culturali nella provincia di Grosseto, Siena, Nuova Immagine, 1995, p. 178-179.
• Aldo Mazzolai, Guida della Maremma. Percorsi tra arte e natura, Florence, Le Lettere, 1997.
• Giuseppe Guerrini, Torri e castelli della provincia di Grosseto, Siena, Nuova Immagine, 1999.

• Borgo Santa Rita
• Castiglioncello Bandini
• Monticello Amiata
• Poggi del Sasso
• Porrona