Sezemice is a municipality and village in Mladá Boleslav District in the Central Bohemian Region of the Czech Republic. It has about 100 inhabitants.

The hamlet of Jirsko 1.díl is an administrative part of Sezemice.

The name is derived from the personal name Sezema, meaning "the village of Sezema's people".

Sezemice is located about 19 kilometres (12 mi) north of Mladá Boleslav and 18 km (11 mi) south of Liberec. It lies in the Jičín Uplands. The highest point is at 350 m (1,150 ft) above sea level.

The first written mention of Sezemice is from 1115, when Duke Vladislaus I donated the village to the newly established monastery in Kladruby. The owners of the village included Jan Čapek of Sány and the Wartenberg family. From the mid-16th century until the 19th century, Sezemice was part of the Svijany estate and shared its owners, among whom were the families of Wartenberg, Schlick and Waldstein.

Historical population

Year Pop. ±% 1869 321 —     1880 309 −3.7% 1890 287 −7.1% 1900 304 +5.9% 1910 273 −10.2%	Year Pop. ±% 1921 289 +5.9% 1930 265 −8.3% 1950 209 −21.1% 1961 196 −6.2% 1970 166 −15.3%	Year Pop. ±% 1980 142 −14.5% 1991 108 −23.9% 2001 103 −4.6% 2011 109 +5.8% 2021 108 −0.9%
Source: Censuses

There are no railways or major roads passing through the municipality.

The main landmark of Sezemice is the Church of Saint Bartholomew. Its existence was first documented in 1352. In 1852–1856, the church was rebuilt into its current Empire form.

• Stanislav Libenský (1921–2002), contemporary artist

• Official website