South Carolina Highway 80 (SC 80) is a 5.620-mile (9.045 km) primary state highway in the state of South Carolina. The highway serves as a bypass, connecting SC 14 to U.S. Route 29 (US 29) in Greer.

SC 80 is a four-lane expressway, which begins at SC 14, on the backside of the Greenville-Spartanburg International Airport. Going in a northeasterly direction, the first 0.8 miles (1.3 km) include a narrow median before splitting into a divided highway. Top speed limit along the highway is 55 miles per hour (89 km/h) with several at-grade intersections and one grade-separated intersection. The highway ends at US 29 (Wade Hampton Boulevard). The highway is shared with truck routes of SC 101 and SC 290.

The second incarnation of SC 80 was established in July 2002 as a new primary route running from SC 101 to US 29. In April 2005 it was extended to SC 14.

The first SC 80 existed from 1937 to 1962 as a new primary route from SC 181 in Fair Play to SC 18 in Anderson. It was decommissioned after Lake Hartwell formed a gap in the highway with the westernmost part becoming part of SC 243 and the rest becoming Old Dobbins Bridge Road (S-4-22 and S-4-23).

The entire route is in Greer.

County	mi	km	Destinations	Notes
Greenville	0.000	0.000	SC 14 / SC 101 Truck north / Tandem Drive west – Greer, Simpsonville	Western end of SC 101 Truck concurrency; western terminus of SC 80; eastern terminus of Tandem Drive
Spartanburg	2.120	3.412	SC 101 (New Woodruff Road) – Greer, Woodruff	Eastern end of SC 101 Truck concurrency; southern terminus of SC 101 Truck
	4.154– 4.170	6.685– 6.711	SC 290 (Poinseet Street) / SC 290 Truck begins – Greer, Duncan	Western end of SC 290 Truck concurrency; eastern terminus of SC 290 Truck; interchange
	5.620	9.045	US 29 / SC 290 Truck west (Wade Hampton Boulevard) / Gary Armstrong Road north – Greer, Lyman	Eastern end of SC 290 Truck concurrency; eastern terminus of SC 80; southern terminus of Gary Armstrong Road
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• U.S. roads portal

• Media related to South Carolina Highway 80 at Wikimedia Commons