The Southern Region of Malawi is an area of Malawi. It covers an area of 31,753 km. Its capital city is Blantyre. In 2018, its population was 7,750,629.

Of the 28 districts in Malawi, 13 are located within the Southern Region. They are: Balaka, Blantyre, Chikwawa, Chiradzulu, Machinga, Mangochi, Mulanje, Mwanza, Neno, Nsanje, Phalombe, Thyolo, and Zomba.

At the time of the 2018 Census of Malawi, the distribution of the population of the Southern Region by ethnic group was as follows:

• 39.3% Lomwe
• 24.9% Yao
• 8.3% Ngoni
• 8.2% Sena
• 6.8% Mang'anja
• 6.6% Chewa
• 3.8% Nyanja
• 0.9% Tumbuka
• 0.4% Tonga
• 0.1% Nkhonde
• 0.0% Lambya
• 0.0% Sukwa
• 0.7% Others