According to the United States Census Bureau, the city has a total area of 20.37 square miles (52.8 km), of which 20.25 square miles (52.4 km) is land and 0.11 square miles (0.28 km) (0.54%) is water. The most common soil series is Cecil. The bedrock is mostly biotite gneiss.

The city of Spartanburg has a humid subtropical climate with long, hot, and humid summers, and cool to semimild winters. The average annual temperature is 61.6 °F (16.4 °C). In the summer from June through September, average highs are in the 80s °F (20s °C) to low 90s °F (30s °C), while in the winter, average highs are in the mid-50s °F (10s °C). Annual rainfall is spread fairly evenly throughout the whole year. Spartanburg receives very little snowfall, with the annual average being only 1.4 inches (3.6 cm). Average precipitation is 51.3 inches (130 cm) and the average growing season is 231 days.

As of the 2020 census, 38,732 people, 15,154 households, and 8,638 families resided in the city.

At the 2010 census, there were 37,013 people, 15,989 households, and 9,721 families residing in the city. The population density was 2,066.3 inhabitants per square mile (797.8/km). The 17,696 housing units had an average density of 923.9 per square mile (356.7/km). The racial makeup was 49.55% African American, 47.15% White, 0.18% Native American, 1.33% Asian, 0.82% from other races, and 0.96% from two or more races. Hispanics or Latinos of any race were 1.78% of the population.

Of the 15,989 households, 28.9% had children under 18 living with them, 34.0% were married couples living together, 23.0% had a female householder with no husband present, and 39.2% were not families. About 34.0% of all households were made up of individuals, and 13.2% had someone living alone who was 65 or older. The average household size was 2.33, and the average family size was 3.00.

In the city, the age distribution was 25.2% under 18, 12.2% from 18 to 24, 26.6% from 25 to 44, 20.6% from 45 to 64, and 15.4% who were 65 or older. The median age was 35 years. For every 100 females, there were 79.6 males.

The median income for a household in the city was $28,735, and for a family was $36,108. Males had a median income of $30,587 versus $23,256 for females. The per capita income for the city was $18,136. About 29.4% of families and 23.3% of the population were below the poverty line, including 34.6% of those under age 18 and 15.4% of those age 65 or over.

Within the past decade, developers and community leaders have spearheaded an effort to revitalize Spartanburg's downtown commercial district. This has resulted in a remodeling of Morgan Square, the restoration of a number of historic structures and the relocation of several businesses and company headquarters to the downtown vicinity. These new developments include a nine-floor, 240-room Marriott hotel.

Spartanburg is home to many large companies, including Denny's, KYMCO, Smith Drug Company, Advance America Cash Advance, Southern Conference, Spartanburg Herald-Journal, RJ Rockers Brewing Company, American Credit Acceptance, and Upward Sports.

The economy of Spartanburg benefits from the BMW manufacturing facility located in the city of Greer, South Carolina, which is in Spartanburg County. As of February 2017, the plant employed around 8,800 people with an average daily output of about 1,400 vehicles.

Spartanburg is also home to the world headquarters and research facility for Milliken & Company, a textile and chemical manufacturer.

According to Spartanburg's 2022 Comprehensive Annual Financial Report, the principal employers in the city are:

Cultural events and institutions in the city include:

• Chapman Cultural Center, Spartanburg's cultural anchor for history, art, theatre, dance, music, and science, is located in a three-building complex on the northern edge of downtown. Opened in October 2007, the Center was designed by David M. Schwarz Architects of Washington, D.C. It houses the Spartanburg Art Museum, Spartanburg County Regional History Museum, Science Center, Little Theatre, Ballet, Music Foundation, and other groups that were formerly located in The Arts Center on South Spring Street. It is owned and operated by The Arts Partnership of Greater Spartanburg, a non-profit organization dedicated to supporting arts and cultural agencies in Spartanburg County.
• Converse University is a nationally known four-year liberal arts institution recognized for its strong music and visual art programs. It hosts events open to the community throughout the year. Twichell Auditorium is located on the campus of Converse University. Home of the Greater Spartanburg Philharmonic Orchestra, Twichell Auditorium has served as hosts to other groups such as the Spartanburg All-County High School Band and Boston Brass. Twichell Auditorium was built in 1899 and renovated for the school's centennial celebration in 1989. The 1500-seat auditorium is home to a 57-rank Casavant organ with 2,600+ pipes. Theatre Converse puts on several plays a year, and Converse puts on an opera annually, as well as opera scenes. The university has had major concerts in recent years with such artists as Caedmon's Call, Jason Mraz, Corey Smith, and Colbie Caillat.
• Hub City Writers Project, serves the community as a local publishing company and independent bookstore.
• Spartanburg County Public Library headquarters, housed in an innovative building on South Church Street, is home to a voluminous collection of fiction, nonfiction, children's literature, A/V materials and items relating to local history and genealogy. The library hosts many meetings, concerts and presentations. The County Librarian is Todd Stephens.
• Spartanburg Memorial Auditorium is located on N. Church Street, across from the municipal building in the northwest end of the city of Spartanburg. The "SMA" has hosted acts such as Bob Dylan, Crosby Stills and Nash, B.B. King, Billy Joel, David Copperfield, Lewis Grizzard, Harry Connick, Jr., Gerald Levert, Dave Chappelle, Jerry Seinfeld, Phish, A Prairie Home Companion, and many others. Originally built in an Art Deco style and was renovated c. 2002 including a new facade and backstage with loading area.
• Wofford College, liberal arts college. Not traditionally known for its arts and cultural strength, Wofford has made notable strides to develop arts programs in recent years. Poet and environmental writer John E. Lane, theater artist Mark Ferguson, and visual artist Kris Neely are all graduates of Wofford. Each returned to their alma mater to develop curricular and co-curricular opportunities in the Arts, including a Creative Writing program, a Theatre Major, and a minor in Studio Art. John Lane was also a critical visionary in the creation of the Goodall Environmental Studies Center in Glendale.

• Cottonwood Trail, walking trail located in the Edwin M. Griffin Nature Preserve that runs along part of Lawson's Fork Creek. The trail includes picnic areas, a raised path over an extensive wetlands area and access to sporadic sandbars. Located just east of downtown, it is used frequently by cyclists, joggers and walkers. Since the Lawson's Fork floodplain is not suitable for development, wildlife populate the area. Larger animals that can be found here include white-tailed deer, raccoons, wild turkeys, pileated woodpeckers, mallard ducks, Canada geese and snapping turtles.
• Hampton Heights Historic District, the city's oldest intact downtown neighborhood, located a couple of blocks south of Morgan Square. Architectural styles in this neighborhood range from large Queen Anne and Neoclassical homes to cozy early 20th-century bungalows.
• Hatcher Garden and Woodland Preserve, preserve located in the midst of an urban environment. Retired social activist Harold Hatcher and his wife Josephine transformed an eroding gully into a thick woods and flower garden which now provides a haven for birds and other wildlife.

Early European settlers to this area included French fur trappers, English woodsmen, and Scots-Irish farmers. Few remnants survive from these early pioneering days, but traces can be found in the more rural areas of the county.

• Lawson's Fork Creek, tributary of the Pacolet River, was once known for its plentiful wildlife and crystal clear waters. Parks and woodlands line much of its banks (which lie entirely within Spartanburg County), and rocky shoals and natural waterfalls can be found throughout its course. It stretches from the northern end of the county to the eastern end, where it empties into the Pacolet River.
• Jammie Seay House, another 18th-century home, is a more typical representative of a pioneer home. Its single stone fireplace and simple construction were common traits of farmsteads from this period.

First established in the 1780s as a courthouse village, Spartanburg may have been named for the Spartan regiment of the South Carolina militia. The city was incorporated in 1831, at the time of the 50th anniversary of the Battle of Cowpens, a pivotal fight of the American Revolution that took place only a few miles away. The city's streets and architectural record reflect the changes of the 19th and 20th centuries.

• Magnolia Street Train Depot, one of the older buildings in Spartanburg and stands as a reminder of Spartanburg's old nickname "the Hub City," referring to the many transportation routes that connected Spartanburg with cities throughout the region. It is now the home of the Amtrak station, the Hub City Railroad Museum, and the Hub City Farmers' Market.
• Morgan Square, the city's primary downtown hub, is the original courthouse village. It was founded adjacent to a small spring (now underground) on the western slope of a ridge, which forms the border of the Tyger and Pacolet River watersheds. The square's name derives from Daniel Morgan, the general who commanded the American forces at Cowpens. A statue of Morgan was placed in the square in 1881. The oldest existing buildings on Morgan Square date to the 1880s.
• The Price House, the third 18th-century home maintained by the Historical Association, is unique. Its sturdy Flemish-bond brick construction and three stories are less common in this area. By carefully examining the original inventory lists of the house, the Historical Association has been able to retrieve period pieces that approximate the original contents of the house.
• Walnut Grove Plantation, an 18th-century farmhouse, has been preserved by The Spartanburg County Historical Association. The site of a locally famous skirmish during the American Revolutionary War, it was the home of the Moore family. The plantation lies south of Spartanburg near the town of Roebuck, and is open to the public for tours and during annual festivals.

Cotton mills have abounded in the Spartanburg area since 1816, earning Spartanburg the reputation as the "Lowell of the South." Although there were few mills in the area before the Civil War, technological advances, northern capital, and out-migration from the poor farms that made white labor available, created a wave of postbellum mill development here and in much of the Piedmont South. Additionally, the abundant streams and rivers in the area are just beginning their descent towards the lower-lying Midlands region. In many places, these waterways descend abruptly, providing a source for plentiful waterpower. Cotton mills were built along these rivers to harness this power, and so began the region's servitude to King Cotton. These mills, their owners and their slaves dominated the politics and economy of the region for nearly a century. Although nearly all abandoned, many mills remain along the riverbanks, the Piedmont equivalent of Gothic ruins.

• Beaumont Mill, north of the downtown, has recently been purchased by Spartanburg Regional Healthcare who moved their billing, human resources, and medical records to the 180,000-square-foot (17,000 m) mill. The adjacent mill village has been designated as a local historic district.
• Converse Mill, located east of the city along the Pacolet River. It has recently been purchased by a developer. The mill was reconstructed in 1903 after a huge flood washed away the original mill. The dam is still in use by Converse Energy Inc as a hydroelectric plant.

• Glendale Mill, located off Lawson's Fork Creek, southeast of the city. Although gutted by fire in 2004, a few towers and smokestacks remain, providing a dramatic backdrop to the dam, shoals and waterfalls of the creek below. The former company store now serves as the home of the Wofford College Environmental Studies Center. The Glendale Shoals bridge will be getting a $600,000 makeover, and will ultimately connect to the state's Palmetto Trail.

When the United States entered World War I in 1917, one of the sixteen divisional cantonments for the training of National Guard troops was Camp Wadsworth, which is located in the vicinity of Westgate Mall. Large numbers of New York National Guardsmen trained there in addition to many southern troops. During World War II, Camp Croft south of the city trained Army recruits. This is now a South Carolina state park with the same name. Some portions of the park contain the original quonset huts.

• Dickens of a Christmas, Victorian holiday event held annually in downtown Spartanburg on the Tuesday after Thanksgiving.
• The Greek Festival, major street festival that is held in September by the local Greek community at St. Nicholas Greek Orthodox Church. The festival offers Greek food and cultural activities, and is the sister festival to the Greek Festival held every spring in Greenville.
• Festifall, an historical celebration held on the grounds of the 18th-century Walnut Grove Plantation in October, featuring demonstrations and reenactments.
• The Hotspot Skatepark
• The Hub City Farmers Market, outdoor market held Saturday mornings from 8:00am – 12:00pm from April to December at Harvest Park in the Northside neighborhood, showcasing local (often organic) produce and goods.
• The Hub City Hog Fest, annual barbecue festival and competition that benefits Mobile Meals. It is held in the heart of downtown Spartanburg with food trucks, over 40 BBQ teams, and two days of live music.
• Hub City Railroad Museum
• The International Festival, event showcasing culture and cuisine from countries around the globe held at Barnet Park on the first Saturday in October.
• Music on Main, street concert event held every Thursday (April through August) in downtown Spartanburg.
• Spartanburg Music Trail, trail with a series of signs throughout downtown recognizing local musicians.
• Spring Fling, weekend festival typically held the first Saturday of May, has many live artists, rides, and other assorted attractions.
• Red, White and Boom, Fourth of July event held at Barnet Park featuring patriotic music and a fireworks display.
• Taste of the Backcountry, historical celebration held on the grounds of the 18th-century Price House in April, featuring food samples and demonstrations

Spartanburg formerly hosted the NFL's Carolina Panthers training camp each year on the campus of Wofford College from 1995-2023. The Panthers moved their training camp to Charlotte in 2024.

Duncan Park Stadium is one of the oldest baseball stadiums in the country. It was once home to the Spartanburg Stingers in the Coastal Plain League (CPL) and the Spartanburg Crickets in the Southern Collegiate Baseball League. It was also once home to the Spartanburg Peaches, a minor league affiliate of the Cleveland Indians and the Spartanburg Phillies, a minor league team of the Philadelphia Phillies. It now is the home stadium for the baseball teams of Spartanburg High School. In 2021, it was the home field for the Spartanburgers in the CPL.

The Shrine Bowl of the Carolinas is held each year at Wofford's Gibbs Stadium. It is a high school football all-star game played between the top players from South Carolina and the top players from North Carolina.

The USC Upstate Spartans, Spartanburg Methodist College Pioneers, Wofford College Terriers, and Converse University Valkyries offer a variety of sports for both men and women. The Southern Conference is also headquartered in Spartanburg.

The city hosts the Spartanburg Criterium. The criterium is a yearly event and is usually one of the events associated with Speed Week which is part of the USA Crits bicycle racing series. The event is billed as the “fastest night in Spartanburg”.

Upward Sports, a Christian-based sports organization for kids, is headquartered in Spartanburg.

The Down East Wood Ducks baseball team of the Carolina League are planned to move to the currently under-construction Fifth Third Park in downtown Spartanburg in April 2025. The team will be renamed the Hub City Spartanburgers.

Boiling Springs FC, a semiprofessional soccer team of the United Premier Soccer League, began play in 2024.

The current mayor, Jerome Rice, was elected in 2021. Spartanburg operates under a city manager form of government in which the mayor and six city council members have equal votes. Council members represent districts within the city and the mayor is elected at large. The council appoints a city manager, who is responsible for the daily administration of city governmental affairs.

City Hall was located at 145 West Broad Street, however that building was demolished and the city offices are currently located at 187 W Broad Street while a joint joint government complex for the city and county offices is under construction. City council meets on the second and fourth Monday of the month at the Spartanburg County Administration Building.

The Spartanburg County Administration Building (the old Sears building which was vacated in the mid-1970s when Sears moved to Westgate Mall and renovated in the late 1980s or early 1990s) is located at 366 North Church Street. It is across the street from the Spartanburg Memorial Auditorium.

Spartanburg is a college town, with four institutions of higher learning in the city limits:

• Spartanburg Community College Downtown Campus
• Converse University, founded in 1889, Converse University is a comprehensive doctoral institution
• Edward Via College of Osteopathic Medicine (VCOM) – Carolinas Campus, first classes began in fall 2011
• Wofford College, founded in 1854, Wofford College is a Phi Beta Kappa liberal arts college with an enrollment of approximately 1,500 students.

In the area:

• The University of South Carolina Upstate (formerly known as University of South Carolina Spartanburg, or USCS), in Valley Falls
• Spartanburg Community College Spartanburg (Giles) Campus (main campus), in Southern Shops
• Spartanburg Methodist College (formerly known as the Textile Industrial Institute from 1911 to 1942 and then Spartanburg Junior College until 1974), originally the only 2-year residential college in SC, it now offers several 4-year programs; it is located in Saxon.
• Sherman College of Chiropractic, South Carolina's only chiropractic college

Most of the City of Spartanburg's public schools are run by Spartanburg County School District 7, one of seven loosely affiliated districts located in Spartanburg County. District 7 students are zoned to Spartanburg High School. However, the westernmost part of the city is served by Spartanburg County School District 6, which has two elementary schools within city limits. District 6 students are zoned to Paul M. Dorman High School in Roebuck.

The Spartanburg area is home to the main campus of the South Carolina School for the Deaf and the Blind, which is outside of the city limits in an unincorporated area. It has five Regional Outreach Centers throughout the state. The city is also home to Spartanburg Preparatory School, a K–8 public charter school that is the only "brick and mortar" charter school in the Upstate.

Spartanburg is also home to Spartanburg Christian Academy, a K–12 private school in North Spartanburg, the Spartanburg Day School, a K–12 private school offering the International Baccalaureate in grades K–4, and to Oakbrook Preparatory and Westgate Christian schools, both K–12 private schools. Located in Hampton Heights, the Montessori Academy of Spartanburg is a PreK-8 private school providing a Montessori educational approach. The Meeting Street Academy in downtown Spartanburg is a branch of a Charleston-based private school and currently offers PreK and Kindergarten.

St. Paul the Apostle Catholic School is located in downtown Spartanburg. It is affiliated with the Roman Catholic Diocese of Charleston and is K–8.

• The Greer Citizen, publishes online and weekly in print, however, it will close and stop publishing at the end of July 2024
• The Post and Courier of Charleston, operates a bureau in Spartanburg and publishes a Spartanburg e-edition and Spartanburg news online. There is also a free joint print edition from both the Greenville and Spartanburg bureaus published monthly, usually on the fourth Thursday of the month.
• The Spartan Weekly News, weekly newspaper with offices located in downtown Spartanburg. The paper covers all of Spartanburg County with an emphasis on the city of Spartanburg, and its coverage focuses on items of community interest and well as news from around the upstate of South Carolina.
• Spartanburg Herald-Journal, owned by Gannett, is Spartanburg's primary newspaper. The Herald-Journal also publishes Spartanburg magazine four times per year.
• The Woodruff Times, publishes online

Spartanburg is part of the much greater Greenville-Spartanburg-Anderson-Asheville DMA which is the nation's 37th largest in the country and is served by the following major television affiliates:

• Spartanburg was mentioned in the Hank Williams, Jr. 1981 song "Dixie on My Mind".

Spartanburg is served by the Spartanburg Area Regional Transit Agency (SPARTA), covering the city of Spartanburg and the surrounding urbanized area with 8 routes leading to a wide variety of destinations. All SPARTA buses are equipped with bicycle racks. Two hybrid-electric buses were added to the fleet in 2012. The SPARTA Passenger Center is located at 100 North Liberty Street and also serves Greyhound buses.

Mass Transit is provided to all citizens of Spartanburg County through Spartanburg County Dial-A-Ride. It is a door to door service that operates six days a week.

The Greenville-Spartanburg International Airport (GSP) lies mostly in suburban Greer, and it serves Greenville as well as Spartanburg. It has become one of the busiest airports in South Carolina.

The Spartanburg Downtown Memorial Airport (SPA) is a general aviation/small craft airport owned and operated by the City, which lies southwest of town.

Amtrak's Crescent train connects Spartanburg with the cities of New York, Philadelphia, Baltimore, Washington, Greensboro, Charlotte, Atlanta, Birmingham and New Orleans. The Amtrak station is situated at 290 Magnolia Street.

Spartanburg County's healthcare is mainly provided by Spartanburg Regional Healthcare System. Spartanburg Regional is a public, not-for-profit, integrated health care delivery system with several facilities in Spartanburg, including:

• Spartanburg Medical Center (SMC), a research and teaching hospital with two locations: Spartanburg Medical Center campus on East Wood Street and Spartanburg Medical Center — Mary Black Campus on Skylyn Drive. Together, these campuses share a history that stretches back to the 1920s. Spartanburg Medical Center includes a total of 747 beds, and services that include emergency, surgical, maternity, cancer, a Heart Center and inpatient rehabilitation.
• Spartanburg Hospital for Restorative Care (SHRC), a 97-bed long-term, acute-care hospital with a 25-bed skilled nursing facility.
• Gibbs Cancer Center & Research Institute, providing an inpatient oncology unit and outpatient care, along with access to clinical trials and the latest cancer technology.
• Bearden-Josey Center for Breast Health, a state-of-the-art imaging center for digital mammography, ultrasound, stereotactic breast biopsy and bone densitometry.
• Medical Group of the Carolinas, a physician group with offices located throughout Spartanburg and Upstate S.C.

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  Clock tower
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  City Hall
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  Closeup of Morgan Square fountain
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  Part of downtown Spartanburg
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  Citizens and Southern National Bank
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  First Baptist Church
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  High steeple of First Baptist Church
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  First Presbyterian Church
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  St. Paul the Apostle Catholic Church

• List of municipalities in South Carolina

• Cooper, Peter (1997). Hub City Music Makers. Spartanburg, S.C.: Holocene Publishing. ISBN 0-9638731-9-9.
• Landrum, J.B.O. (1900). History of Spartanburg County.
• Racine, Philip N. (1999). Seeing Spartanburg. Spartanburg, S.C.: Hub City Writers Project. ISBN 1-891885-10-3.
• Racine, Philip N. Living a Big War in a Small Place: Spartanburg, South Carolina, during the Confederacy (Univ of South Carolina Press, 2013).
• Teter, Betsy Wakefield (Ed.) (2002). Textile Town: Spartanburg, South Carolina. Spartanburg, S.C.: Hub City Writers Project. ISBN 1-891885-28-6. Pp. 346. 40 authors provide a detailed community study, using oral histories, letters, and 200 illustrations and photographs. Central themes include labor strikes, family life in the mill villages, Depression-era hardships, race and desegregation, the boom of WW2 production, and late-twentieth-century deindustrialization.
• WPA (1939). History of Spartanburg County.

Wikimedia Commons has media related to Spartanburg, South Carolina.

Wikivoyage has a travel guide for Spartanburg.

Wikisource has the text of the 1905 New International Encyclopedia article "Spartanburg, South Carolina".

Wikisource has the text of The New Student's Reference Work article "Spartanburg, South Carolina".

• Geographic data related to Spartanburg, South Carolina at OpenStreetMap
• Official website
• Spartanburg Tourism Commission