Tłokinia Wielka [twɔˈkiɲa ˈvjɛlka] is a village in the administrative district of Gmina Opatówek, within Kalisz County, Greater Poland Voivodeship, in west-central Poland. It lies approximately 3 kilometres (2 mi) north-west of Opatówek, 9 km (6 mi) east of Kalisz, and 114 km (71 mi) south-east of the regional capital Poznań.